Analytical Data
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Gene name
ZNF248
- Application
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Alternative Names
ZNF248; Zinc finger Protein 248
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8NDW4
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Expression Region
1-579 aa
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AA Sequence
MNKSQEQVSF KDVCVDFTQE EWYLLDPAQK ILYRDVILEN YSNLVSVGYC ITKPEVIFKI EQGEEPWILE KGFPSQCHPE RKWKVDDVLE SSQENEDDHF WELLFHNNKT VSVENGDRGS KTFNLGTDPV SLRNYPYKIC DSCEMNLKNI SGLIISKKNC SRKKPDEFNV CEKLLLDIRH EKIPIGEKSY KYDQKRNAIN YHQDLSQPSF GQSFEYSKNG QGFHDEAAFF TNKRSQIGET VCKYNECGRT FIESLKLNIS QRPHLEMEPY GCSICGKSFC MNLRFGHQRA LTKDNPYEYN EYGEIFCDNS AFIIHQGAYT RKILREYKVS DKTWEKSALL KHQIVHMGGK SYDYNENGSN FSKKSHLTQL RRAHTGEKTF ECGECGKTFW EKSNLTQHQR THTGEKPYEC TECGKAFCQK PHLTNHQRTH TGEKPYECKQ CGKTFCVKSN LTEHQRTHTG EKPYECNACG KSFCHRSALT VHQRTHTGEK PFICNECGKS FCVKSNLIVH QRTHTGEKPY KCNECGKTFC EKSALTKHQR THTGEKPYEC NACGKTFSQR SVLTKHQRIH TRVKALSTS
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Molecular Weight
67 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZNF248, also known as zinc finger protein 248, is a member of the Krüppel-like family of transcription factors, characterized by its zinc-finger motifs that facilitate DNA binding. This protein plays a crucial role in gene regulation and is implicated in various cellular processes, including development, cell differentiation, and response to cellular stress. Recent studies have suggested that ZNF248 is involved in regulating genes associated with stem cell maintenance, neural differentiation, and possibly tumorigenesis, indicating its significance in both developmental biology and cancer research. The investigation of recombinant ZNF248 protein has garnered attention as researchers aim to elucidate its functional mechanisms and potential interactions with other molecular pathways. Producing ZNF248 as a recombinant protein allows for detailed biochemical studies, providing insights into its structural properties and binding affinities. Moreover, understanding the pathways regulated by ZNF248 may reveal novel therapeutic targets for stem cell-related disorders and cancers, making it a prominent focus in molecular biology and medical research. Ongoing efforts to express and purify ZNF248 in various systems aim to facilitate further investigation into its role and significance within the cellular context, thereby advancing our understanding of its biological functions and therapeutic potential.
