Analytical Data
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Gene name
TMEM9
- Application
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Alternative Names
TMEM9; DERP4; TMEM9A; HSPC186; PSEC0012; UNQ631/PRO1248; Transmembrane Protein 9; Dermal papilla-derived Protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9P0T7
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Expression Region
1-183 aa
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AA Sequence
MKLLSLVAVVGCLLVPPAEANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHKMLS
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Molecular Weight
47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMEM9 (Transmembrane Protein 9) is a membrane protein that has garnered attention in recent years due to its potential role in various cellular processes, including endosomal trafficking and immune response. Studies have shown that TMEM9 is involved in the regulation of autophagy and the immune system's response to pathogens, particularly in the context of viral infections. Its structure, which includes multiple transmembrane domains, suggests it may interact with other proteins and cellular compartments, influencing signaling pathways that are crucial for cellular homeostasis and function. Research has indicated that alterations in TMEM9 expression or function could be linked to various diseases, including cancer and neurodegenerative disorders, making it a target of interest for therapeutic interventions. The production of recombinant TMEM9 protein is essential for understanding its structure-function relationship and elucidating its role in cellular mechanisms. By employing techniques such as molecular cloning and expression in suitable host systems, researchers can generate sufficient quantities of TMEM9 for biophysical studies and functional assays. This research could ultimately pave the way for developing novel strategies to manipulate TMEM9-related pathways in disease contexts, highlighting the importance of TMEM9 in modern biomedical research.
