Analytical Data
-
基因名
FXR
- Application
-
别名
FXR；FMR1L2；RNA-binding Protein FXR2
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q96RI1
-
表达区间
1-476aa
-
氨基酸序列
MGSKMNLIEHSHLPTTDEFSFSENLFGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
-
分子量
70.7kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The research on FXR (Farnesoid X Receptor) recombinant proteins has gained significant attention due to its critical role in regulating various physiological processes, particularly in liver and metabolic systems. FXR is a nuclear receptor that acts as a key regulator of bile acid homeostasis, lipid metabolism, and glucose metabolism. Abnormal FXR function has been linked to several metabolic diseases, including non-alcoholic fatty liver disease (NAFLD), obesity, and type 2 diabetes. The understanding of FXR's mechanisms at the molecular level has opened up new therapeutic avenues for treating these conditions. The development of recombinant FXR proteins allows for detailed studies of its structural and functional properties, providing insights into how FXR interacts with its ligands and regulates gene expression. Additionally, these recombinant proteins can be utilized in drug discovery and development processes, facilitating the screening of potential FXR activators or inhibitors. Overall, research on FXR recombinant proteins is pivotal in elucidating the receptor’s role in metabolic regulation and offers promising prospects for innovative treatments for metabolic disorders.
