Analytical Data
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Gene name
FXR
- Application
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Alternative Names
FXR；FMR1L2；RNA-binding Protein FXR2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96RI1
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Expression Region
1-476aa
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AA Sequence
MGSKMNLIEHSHLPTTDEFSFSENLFGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ
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Molecular Weight
70.7kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on FXR (Farnesoid X Receptor) recombinant proteins has gained significant attention due to its critical role in regulating various physiological processes, particularly in liver and metabolic systems. FXR is a nuclear receptor that acts as a key regulator of bile acid homeostasis, lipid metabolism, and glucose metabolism. Abnormal FXR function has been linked to several metabolic diseases, including non-alcoholic fatty liver disease (NAFLD), obesity, and type 2 diabetes. The understanding of FXR's mechanisms at the molecular level has opened up new therapeutic avenues for treating these conditions. The development of recombinant FXR proteins allows for detailed studies of its structural and functional properties, providing insights into how FXR interacts with its ligands and regulates gene expression. Additionally, these recombinant proteins can be utilized in drug discovery and development processes, facilitating the screening of potential FXR activators or inhibitors. Overall, research on FXR recombinant proteins is pivotal in elucidating the receptor’s role in metabolic regulation and offers promising prospects for innovative treatments for metabolic disorders.
