Analytical Data
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Gene name
UQCRB
- Application
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Alternative Names
UQCRB；UQBP；Cytochrome b-c1 complex subunit 7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P14927
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Expression Region
2-111aa
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AA Sequence
AGKQAVSAS GKWLDGIRKW YYNAAGFNKL GLMRDDTIYE DEDVKEAIRR LPENLYNDRM FRIKRALDLN LKHQILPKEQ WTKYEEENFY LEPYLKEVIR ERKEREEWAK K
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UQCRB, or Ubiquinol-Cytochrome c Reductase Binding Protein, is a crucial component of the mitochondrial respiratory chain complex III, playing a significant role in cellular energy production and oxidative phosphorylation. The study of UQCRB is essential because it is involved in the electron transport chain, which is fundamental for ATP synthesis in eukaryotic cells. Abnormalities in the expression or function of UQCRB have been linked to various metabolic disorders and neurodegenerative diseases, highlighting its importance in maintaining mitochondrial health and cellular metabolism. Research into UQCRB focuses on understanding its structural properties, binding interactions, and regulatory mechanisms, as well as its potential implications in therapeutic applications. Overall, investigating UQCRB and its recombinant protein forms can provide insights into mitochondrial dysfunction and open new avenues for drug development aimed at mitigating diseases associated with impaired energy metabolism.
