Analytical Data
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Gene name
TMEM41A
- Application
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Alternative Names
TMEM41A; UNQ168/PRO194; Transmembrane Protein 41A
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96HV5
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Expression Region
1-264 aa
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AA Sequence
MRPLLGLLLVFAGCTFALYLLSTRLPRGRRLGSTEEAGGRSLWFPSDLAELRELSEVLREYRKEHQAYVFLLFCGAYLYKQGFAIPGSSFLNVLAGALFGPWLGLLLCCVLTSVGATCCYLLSSIFGKQLVVSYFPDKVALLQRKVEENRNSLFFFLLFLRLFPMTPNWFLNLSAPILNIPIVQFFFSVLIGLIPYNFICVQTGSILSTLTSLDALFSWDTVFKLLAIAMVALIPGTLIKKFSQKHLQLNETSTANHIHSRKDT
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Molecular Weight
56.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMEM41A, a member of the transmembrane protein family, has garnered significant attention in the field of cellular biology and disease research due to its critical roles in cellular processes. It is primarily implicated in regulating lysosomal function, autophagy, and lipid metabolism. Recent studies have shown that TMEM41A mutations are associated with neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), underscoring its importance in maintaining neuronal health. The understanding of TMEM41A’s function has been further advanced by the development of recombinant TMEM41A proteins, allowing for in-depth characterization of its biochemical properties and interactions with other cellular components. These studies typically involve the expression of TMEM41A in various cellular models, enabling researchers to elucidate its mechanisms of action and potential pathways leading to cellular dysfunction. This research not only sheds light on the fundamental biology of TMEM41A but also opens avenues for targeted therapeutic strategies aimed at mitigating the effects of its dysfunction in diseases. The generation of recombinant TMEM41A protein serves as a crucial tool for structural and functional studies, potentially leading to a better understanding of its roles in health and disease.
