Analytical Data
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基因名
PANX1
- Application
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别名
PANX1；MRS1；Pannexin-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96RD7
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表达区间
1-426aa
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氨基酸序列
MAIAQLATEYVFSDFLLKEPTEPKFKGLRLELAVDKMVTCIAVGLPLLLISLAFAQEISI GTQISCFSPSSFSWRQAAFVDSYCWAAVQQKNSLQSESGNLPLWLHKFFPYILLLFAILL YLPPLFWRFAAAPHICSDLKFIMEELDKVYNRAIKAAKSARDLDMRDGACSVPGVTENLG QSLWEVSESHFKYPIVEQYLKTKKNSNNLIIKYISCRLLTLIIILLACIYLGYYFSLSSL SDEFVCSIKSGILRNDSTVPDQFQCKLIAVGIFQLLSVINLVVYVLLAPVVVYTLFVPFR QKTDVLKVYEILPTFDVLHFKSEGYNDLSLYNLFLEENISEVKSYKCLKVLENIKSSGQG IDPMLLLTNLGMIKMDVVDGKTPMSAEMREEQGNQTAELQGMNIDSETKANNGEKNARQR LLDSSC
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Panx1 (Pannexin 1) is a channel-forming protein that plays a critical role in cell communication and is implicated in numerous physiological and pathological processes, including extracellular ATP release, neuronal signaling, and inflammatory responses. Its unique structure enables the passage of ions and small molecules, making it essential for maintaining cellular homeostasis and facilitating intercellular communication. Research has indicated that Panx1 is involved in various diseases, such as cancer, neurodegenerative disorders, and cardiovascular conditions, which has spurred interest in understanding its functional mechanisms and therapeutic potential. The recombinant expression of Panx1 protein offers a valuable tool for studying its properties, as it allows researchers to produce pure proteins for structural and functional analyses. By investigating the biophysical characteristics, regulatory mechanisms, and interaction partners of Panx1, scientists aim to clarify its role in disease and identify potential therapeutic targets. Overall, the study of Panx1 recombinant protein is pivotal for elucidating the biological significance of this channel and for the development of novel strategies to manage diseases associated with its dysregulation.
