Analytical Data
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基因名
TMEM41B
- Application
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别名
TMEM41B; KIAA0033; Transmembrane Protein 41B; Protein stasimon
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5BJD5
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表达区间
1-192 aa
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氨基酸序列
MAKGRVAERSQLGAHHTTPVGDGAAGTRGLAAPGSRDHQKEKSWVEAGSARMSLLILVSIFLSAAFVMFLVYKNFPQLSEEERVNMKVPRDMDDAKALGKVLSKYKDTFYVQVLVAYFATYIFYQLANICYSRLYISQYTLRVSLSLSTSLISCLFVFWTWCLFLLYAFLFSWETSCIQIPNRESSKMVTAG
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分子量
48.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMEM41B (Transmembrane Protein 41B) has emerged as a significant player in the study of cellular processes related to autophagy, lipid metabolism, and neurological diseases. Initially identified through genome-wide association studies as being associated with conditions such as Alzheimer’s disease, TMEM41B is increasingly recognized for its role in regulating autophagosome formation and maturation. Research has shown that TMEM41B interacts with critical proteins involved in the autophagic process, suggesting it may serve as a regulatory hub within this essential cellular pathway. Moreover, its involvement in lipid homeostasis highlights its potential implications in metabolic disorders. The recombinant expression of TMEM41B allows for the detailed study of its functional properties and interactions, which can shed light on its biological roles and potentially identify therapeutic targets for diseases linked to autophagy dysregulation. Thus, the generation and characterization of TMEM41B recombinant protein are pivotal in advancing our understanding of its molecular mechanisms and contributions to human health and disease.
