Analytical Data
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基因名
UBE2L3
- Application
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别名
UBE2L3；UBCE7；UBCH7；Ubiquitin-conjugating enzyme E2 L3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P68036
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表达区间
1-154aa
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氨基酸序列
MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGA FRIEINFPAEYPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATK TDQVIQSLIALVNDPQPEHPLRADLAEEYSKDRKKFCKNAEEFTKKYGEK RPVD
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
UBE2L3, a member of the ubiquitin-conjugating enzyme family, plays a crucial role in the post-translational modification of proteins through ubiquitination, a process essential for regulating various cellular functions, including protein degradation, cell cycle progression, and DNA repair. Research has increasingly highlighted UBE2L3’s involvement in numerous biological processes and diseases, including cancer, immune response, and viral infections. Elevated levels of UBE2L3 have been associated with various malignancies, suggesting that it may serve as a potential biomarker or therapeutic target. Furthermore, its interaction with different E3 ligases and substrates underscores its regulatory complexity in the ubiquitin-proteasome system. Understanding the precise functions and mechanisms of UBE2L3 through recombinant protein studies can provide insights into its role in cellular homeostasis and disease pathology. This knowledge may facilitate the development of novel interventions aimed at modulating UBE2L3 activity for therapeutic purposes, emphasizing the significance of UBE2L3 in both fundamental biology and translational medicine.
