Analytical Data
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Gene name
ERGIC1
- Application
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Alternative Names
ERGIC1; ERGIC32; KIAA1181; HT034; Endoplasmic reticulum-Golgi intermediate compartment protein 1; ER-Golgi intermediate compartment 32 kDa protein; ERGIC-32
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q969X5
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Expression Region
1-290aa
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AA Sequence
MPFDFRRFDIYRKVPKDLTQPTYTGAIISICCCLFILFLFLSELTGFITTEVVNELYVDDPDKDSGGKIDVSLNISLPNLHCELVGLDIQDEMGRHEVGHIDNSMKIPLNNGAGCRFEGQFSINKVPGNFHVSTHSATAQPQNPDMTHVIHKLSFGDTLQVQNIHGAFNALGGADRLTSNPLASHDYILKIVPTVYEDKSGKQRYSYQYTVANKEYVAYSHTGRIIPAIWFRYDLSPITVKYTERRQPLYRFITTICAIIGGTFTVAGILDSCIFTASEAWKKIQLGKMH
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Molecular Weight
59 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ERGIC1 (Endoplasmic Reticulum-Golgi Intermediate Compartment 1) is a crucial protein that plays a significant role in the secretory pathway of eukaryotic cells. It is primarily located in the endoplasmic reticulum-Golgi intermediate compartment, where it is involved in the transport of proteins between the endoplasmic reticulum and the Golgi apparatus. The study of ERGIC1 is important due to its involvement in maintaining the integrity of the cell's secretory processes and its potential link to various diseases, including neurodegenerative disorders and certain types of cancer. Recent research has focused on understanding the structure and function of ERGIC1, its interactions with other cellular proteins, and its regulatory mechanisms in cargo trafficking. Furthermore, alterations in ERGIC1 function can lead to disruptions in protein secretion, contributing to pathological conditions. Thus, investigating ERGIC1 not only enhances our understanding of cellular transport mechanisms but may also reveal novel therapeutic targets for diseases associated with impaired secretion.
