Analytical Data
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Gene name
ERCC6L
- Application
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Alternative Names
ATP dependent helicase ERCC6 like; ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC 6 like; DNA excision repair protein ERCC-6-like; ERC6L_HUMAN; ERCC 6L; Ercc6l; Excision repair cross complementing rodent repair deficiency complementation group 6 like; Excision repair protein ERCC6 like; FLJ20105
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q2NKX8
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Expression Region
1-419aa
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AA Sequence
MEKSFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHCNPWPIISITNESQNAESNVSIIEIADDLSASHSALQDAQASEAKLEEEPSASSPQYACDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGSAPNSRAGFVHSKTCLSWEFSEKDDEPEEVVVKAKIRSKARRIVSDGEDEDDSFKDTSSINPFNTSLFQFSSVKQFDASTPKNDISPPGRFFSSQIPSSVNKSMNSRRSLASRRSLINMVLDHVEDMEERLDDSSEAKGPEDYPEEGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALAQETSLGAPEPLSGEQLVGSPQDKAAEATNDYETLVKRGKELKECGKIQEALNCLVKALDIKSADPEVMLLTLSLYKQLNNN
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Molecular Weight
71.61 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ERCC6L (Excision Repair Cross-Complementation Group 6-Like) is a critical protein involved in DNA repair processes, particularly in the context of maintaining genomic stability. Its significance is underscored by its role in the nucleotide excision repair (NER) pathway, which is vital for correcting DNA lesions caused by environmental damage, such as UV radiation, and by metabolic byproducts. Mutations or dysfunctions in ERCC6L are implicated in various genetic disorders, including some cancer predisposition syndromes, highlighting its importance in therapeutic contexts. Recent studies suggest that ERCC6L not only participates in DNA repair but also plays a role in regulating cellular responses to stress and apoptosis. The recombinant protein research has focused on elucidating its structure-function relationships to better understand its mechanistic roles in DNA repair pathways. Researchers aim to generate ERCC6L variants to examine their functional implications and potential as therapeutic targets. This understanding of ERCC6L's biological functions and its interactions with other DNA repair proteins could pave the way for novel interventions in cancer therapy and gene therapy strategies, thereby addressing the critical challenges posed by genomic instability diseases. As our knowledge of ERCC6L expands, it opens new avenues for exploring the intricate molecular networks involved in DNA repair, offering potential for innovative approaches to combat diseases linked to impaired DNA damage response mechanisms.
