Analytical Data
-
基因名
ERCC6L
- Application
-
别名
ATP dependent helicase ERCC6 like; ATP-dependent helicase ERCC6-like; DNA excision repair protein ERCC 6 like; DNA excision repair protein ERCC-6-like; ERC6L_HUMAN; ERCC 6L; Ercc6l; Excision repair cross complementing rodent repair deficiency complementation group 6 like; Excision repair protein ERCC6 like; FLJ20105
-
种属
Human
-
表达系统
E. coli
-
标签
GST-tag at N-terminal
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
Q2NKX8
-
表达区间
1-419aa
-
氨基酸序列
MEKSFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHCNPWPIISITNESQNAESNVSIIEIADDLSASHSALQDAQASEAKLEEEPSASSPQYACDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGSAPNSRAGFVHSKTCLSWEFSEKDDEPEEVVVKAKIRSKARRIVSDGEDEDDSFKDTSSINPFNTSLFQFSSVKQFDASTPKNDISPPGRFFSSQIPSSVNKSMNSRRSLASRRSLINMVLDHVEDMEERLDDSSEAKGPEDYPEEGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALAQETSLGAPEPLSGEQLVGSPQDKAAEATNDYETLVKRGKELKECGKIQEALNCLVKALDIKSADPEVMLLTLSLYKQLNNN
-
分子量
71.61 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ERCC6L (Excision Repair Cross-Complementation Group 6-Like) is a critical protein involved in DNA repair processes, particularly in the context of maintaining genomic stability. Its significance is underscored by its role in the nucleotide excision repair (NER) pathway, which is vital for correcting DNA lesions caused by environmental damage, such as UV radiation, and by metabolic byproducts. Mutations or dysfunctions in ERCC6L are implicated in various genetic disorders, including some cancer predisposition syndromes, highlighting its importance in therapeutic contexts. Recent studies suggest that ERCC6L not only participates in DNA repair but also plays a role in regulating cellular responses to stress and apoptosis. The recombinant protein research has focused on elucidating its structure-function relationships to better understand its mechanistic roles in DNA repair pathways. Researchers aim to generate ERCC6L variants to examine their functional implications and potential as therapeutic targets. This understanding of ERCC6L's biological functions and its interactions with other DNA repair proteins could pave the way for novel interventions in cancer therapy and gene therapy strategies, thereby addressing the critical challenges posed by genomic instability diseases. As our knowledge of ERCC6L expands, it opens new avenues for exploring the intricate molecular networks involved in DNA repair, offering potential for innovative approaches to combat diseases linked to impaired DNA damage response mechanisms.
