Analytical Data
-
基因名
AHRR
- Application
-
别名
AHRR；BHLHE77；KIAA1234；Aryl hydrocarbon receptor repressor
-
种属
Human
-
表达系统
E. coli
-
标签
His tag N-Terminus
-
纯度
Greater than 90% as determined by SDS-PAGE.
-
蛋白编号
P04798
-
表达区间
1-512aa
-
氨基酸序列
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
-
分子量
63.7 kDa
-
内毒素
< 1.0 EU per μg protein as determined by the LAL method.
-
性状
Freeze-dried powder
-
缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
-
稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The AHRR (Aryl Hydrocarbon Receptor Repressor) protein is a significant focus in biomedical research due to its role as a key regulator in the signaling pathways mediated by the Aryl Hydrocarbon Receptor (AhR). AhR is a ligand-activated transcription factor that regulates various biological processes, including immune response, cell proliferation, and differentiation, mainly in response to environmental pollutants like dioxins. AHRR, as a repressor, provides a negative feedback loop by inhibiting the transcriptional activity of AhR, thus playing a critical role in maintaining cellular homeostasis and protecting against the potential adverse effects of excessive AhR activation, which can lead to toxic responses and contribute to carcinogenesis. Understanding the molecular mechanisms underlying AHRR's function has garnered attention for its potential implications in cancer biology, toxicology, and environmental health. Recent studies have explored the epigenetic regulation of AHRR expression and its involvement in various diseases, highlighting its potential as a biomarker or therapeutic target. The investigation of AHRR's role in modulating AhR activity presents a valuable avenue for developing strategies to mitigate the negative impacts of environmental toxins and improve health outcomes.
