Analytical Data
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基因名
TMEM126B
- Application
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别名
TMEM126B; HT007; Complex I assembly factor TMEM126B. mitochondrial; Transmembrane Protein 126B
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IUX1
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表达区间
1-200 aa
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氨基酸序列
MAASMHGQPSPSLEDAKLRRPMVIEIIEKNFDYLRKEMTQNIYQMATFGTTAGFSGIFSNFLFRRCFKVKHDALKTYASLATLPFLSTVVTDKLFVIDALYSDNISKENCVFRSSLIGIVCGVFYPSSLAFTKNGRLATKYHTVPLPPKGRVLIHWMTLCQTQMKLMAIPLVFQIMFGILNGLYHYAVFEETLEKTIHEE
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分子量
49.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMEM126B, a member of the transmembrane protein family, has garnered attention in recent years due to its potential roles in various cellular processes. It is implicated in mitochondrial dynamics, including fusion and fission, which are critical for maintaining mitochondrial function and cellular homeostasis. Dysregulation of these processes is associated with several diseases, including neurodegenerative disorders and metabolic syndromes. Furthermore, studies have indicated that TMEM126B may participate in signaling pathways that affect cell survival and apoptosis. Research efforts have focused on the recombinant expression and purification of TMEM126B to elucidate its structure-function relationships and to explore its interactions with other cellular components. The generation of recombinant TMEM126B protein allows for in-depth biochemical and biophysical analyses, providing insights into its mechanistic roles in mitochondrial biology. Understanding TMEM126B's function could reveal new therapeutic targets for diseases linked to mitochondrial dysfunction. Overall, the study of TMEM126B and its recombinant protein holds promise for advancing our knowledge of cellular processes and developing novel strategies for disease intervention.
