Analytical Data
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Gene name
TMCO7
- Application
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Alternative Names
TANGO6; KIAA1746; TMCO7; Transport and Golgi organization Protein 6 homolog; Transmembrane and coiled-coil domain-containing Protein 7
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9C0B7
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Expression Region
1-334 aa
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AA Sequence
MAARQAVGSGAQETCGLDRILEALKLLLSPGGSGSSSLQVTKHDVLLATLKSNLSALEDKFLKDPQWKNLKLLRDEIADKAEWPQNSVDVTWSFTSQTLLLLLCLKETMIRLAANFNPGKPNPRTPEVAPALSPDALSISQQKTVQFVLQFVVTLGICPYLMPGVGVPLRYRTEFGAVVQDVVCFDAAPDATRRLYTSCKALLNVAQHTSLGSLIFCHHFGDIAAGLCQLGFCPTKRKLLTPAEEVLTEEERTLSRGALRDMLDQVYQPLAVRELLILQGGPPQSCTDVKTQMRCRAPAWLRRLCGQLLSERLMRPNGVQAVVRGILEGAGGKK
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Molecular Weight
62.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TMCO7, a member of the Transmembrane and Coiled-Coil Domains 7 (TMCO) protein family, has garnered increasing attention in the fields of molecular biology and biochemistry due to its potential role in cellular processes, particularly in the endoplasmic reticulum (ER) and calcium homeostasis. Research indicates that TMCO7 may be involved in the regulation of ion channels and the maintenance of ER calcium levels, which are critical for various physiological functions, including protein folding, signaling, and cell survival. The understanding of TMCO7 is still in its nascent stages; however, preliminary studies suggest that its dysfunction could be linked to certain diseases, making it a potential target for therapeutic intervention. Ongoing research aims to elucidate its specific functions, interactions, and mechanisms of action within the cell, with an emphasis on its structure-function relationship. The heterologous expression and characterization of TMCO7 as a recombinant protein are vital steps in studying its detailed biochemical properties and elucidating its role in health and disease. This knowledge may pave the way for novel strategies in treating disorders related to calcium dysregulation and ER stress.
