Analytical Data
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Gene name
POMP
- Application
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Alternative Names
POMP；C13orf12；UMP1；Proteasome maturation Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y244
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Expression Region
1-141aa
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AA Sequence
MNARGLGSEL KDSIPVTELS ASGPFESHDL LRKGFSCVKN ELLPSHPLEL SEKNFQLNQD KMNFSTLRNI QGLFAPLKLQ MEFKAVQQVQ RLPFLSSSNL SLDVLRGNDE TIGFEDILND PSQSEVMGEP HLMVEYKLGL L
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
POMP, or proteasome maturation protein, plays a crucial role in the assembly and functionality of the 26S proteasome, which is essential for degrading damaged proteins and regulating various cellular processes, including the cell cycle and apoptosis. Research into POMP has garnered attention due to its involvement in the proteasome's biogenesis and its potential implications in diseases such as cancer and neurodegenerative disorders, where proteasome activity is often compromised. Understanding POMP’s function and the mechanisms by which it facilitates proteasome assembly can provide insights into therapeutic strategies aimed at restoring proteasome activity. Studies have shown that POMP interacts with various proteins throughout the maturation process of the proteasome, underscoring its significance in cellular homeostasis. Moreover, alterations in POMP expression levels have been linked to tumor progression, making it a potential biomarker for cancer diagnosis and treatment. Recent advancements in biotechnological methods, including cryo-electron microscopy and advanced mass spectrometry, have enabled researchers to explore the structural dynamics of POMP and its associated complexes in unprecedented detail. This growing body of research highlights the importance of POMP not only in basic cellular biology but also in the development of novel therapeutic approaches targeting proteasome dysfunctions across various diseases.
