Analytical Data
-
Gene name
EML4-ALK
- Application
-
Alternative Names
Alk; ALK tyrosine kinase receptor; ALK/EML4 fusion gene; included; ALK/NPM1 fusion gene; included; ALK_HUMAN; anaplastic lymphoma kinase (Ki-1); Anaplastic lymphoma kinase; Anaplastic lymphoma kinase Ki1; anaplastic lymphoma receptor tyrosine kinase; CD 246
-
Species
Human
-
Source
E. coli
-
Tag
GST-tag at N-terminal
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9UM73
-
Expression Region
1-496aa
-
AA Sequence
MGAIGLLWLLPLLLSTAAVGSGMGTGQRAGSPAAGPPLQPREPLSYSRLQRKSLAVDFVVPSLFRVYARDLLLPPSSSELKAGRPEARGSLALDCAPLLRLLGPAPGVSWTAGSPAPAEARTLSRVLKGGSVRKLRRAKQLVLELGEEAILEGCVGPPGEAAVGLLQFNLSELFSWWIRQGEGRLRIRLMPEKKASEVGREGRLSAAIRASQPRLLFQIFGTGHSSLESPTNMPSPSPDYFTWNLTWIMKDSFPFLSHRSRYGLECSFDFPCELEYSPPLHDLRNQSWSWRRIPSEEASQMDLLDGPGAERSKEMPRGSFLLLNTSADSKHTILSPWMRSSSEHCTLAVSVHRHLQPSGRYIAQLLPHNEAAREILLMPTPGKHGWTVLQGRIGRPDNPFRVALEYISSGNRSLSAVDFFALKNCSEGTSPGSKMALQSSFTCWNGTVLQLGQACDFHQDCAQGEDESQMCRKLPVGFYCNFEDGFCGWTQGTLSP
-
Molecular Weight
150 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
EMR4 (EGF-like module-containing mucin-like hormone receptor-like 4) is a critical receptor implicated in various physiological processes and diseases. Emerging studies suggest that EMR4 plays a significant role in immune regulation and inflammation, highlighting its potential as a therapeutic target for conditions such as autoimmune disorders and cancers. The receptor's unique structure, characterized by a series of EGF-like repeats, endows it with distinct binding properties and downstream signaling capabilities, which are not yet fully understood. Recent advancements in recombinant protein technology have facilitated the production and purification of EMR4, allowing for detailed studies of its structure-function relationships. Researchers are exploring the detailed mechanisms by which EMR4 influences immune cell function, interactions with other receptors, and its role in modulating inflammatory responses. This research not only enhances our understanding of EMR4's biological significance but also paves the way for developing novel therapeutic strategies targeting EMR4 in various disease contexts. As a consequence, studies on EMR4 recombinant proteins are of paramount relevance in biomedical research, aiming to elucidate their potential for clinical applications.
