Analytical Data
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基因名
TIMM8B
- Application
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别名
TIMM8B; DDP2; DDPL; TIM8B; Mitochondrial import inner membrane translocase subunit Tim8 B; DDP-like Protein; Deafness dystonia Protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y5J9
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表达区间
2-83 aa
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氨基酸序列
AELGEADEA ELQRLVAAEQ QKAQFTAQVH HFMELCWDKC VEKPGNRLDS RTENCLSSCV DRFIDTTLAI TSRFAQIVQK GGQ
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分子量
9.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIMM8B, or Translocase of Inner Mitochondrial Membrane 8B, is a protein that plays a critical role in the import of mitochondrial proteins, particularly those containing a presequence targeting signal. Research on TIMM8B has gained significance due to its association with various mitochondrial diseases, particularly those that lead to defects in mitochondrial function. Mutations in the TIMM8B gene have been linked to disorders such as Wolfram syndrome and other neurodegenerative conditions, highlighting its importance in cellular energy metabolism and overall mitochondrial health. The study of recombinant TIMM8B protein is crucial for understanding its structure-function relationships and mechanisms of action, as well as for characterizing its interactions with other mitochondrial proteins. By producing TIMM8B in a recombinant system, researchers can investigate the protein's biochemical properties, its role in mitochondrial biogenesis, and its involvement in mitochondrial dynamics. This research not only aids in elucidating the molecular underpinnings of diseases associated with TIMM8B deficiencies but also has potential implications for therapeutic strategies, including gene therapy and targeted drug design aimed at restoring mitochondrial function in affected individuals. Overall, the investigation of TIMM8B through recombinant protein studies is a vital step towards advancing our knowledge of mitochondrial biology and developing innovative treatments for related disorders.
