Analytical Data
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Gene name
TIMM8B
- Application
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Alternative Names
TIMM8B; DDP2; DDPL; TIM8B; Mitochondrial import inner membrane translocase subunit Tim8 B; DDP-like Protein; Deafness dystonia Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5J9
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Expression Region
2-83 aa
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AA Sequence
AELGEADEA ELQRLVAAEQ QKAQFTAQVH HFMELCWDKC VEKPGNRLDS RTENCLSSCV DRFIDTTLAI TSRFAQIVQK GGQ
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Molecular Weight
9.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIMM8B, or Translocase of Inner Mitochondrial Membrane 8B, is a protein that plays a critical role in the import of mitochondrial proteins, particularly those containing a presequence targeting signal. Research on TIMM8B has gained significance due to its association with various mitochondrial diseases, particularly those that lead to defects in mitochondrial function. Mutations in the TIMM8B gene have been linked to disorders such as Wolfram syndrome and other neurodegenerative conditions, highlighting its importance in cellular energy metabolism and overall mitochondrial health. The study of recombinant TIMM8B protein is crucial for understanding its structure-function relationships and mechanisms of action, as well as for characterizing its interactions with other mitochondrial proteins. By producing TIMM8B in a recombinant system, researchers can investigate the protein's biochemical properties, its role in mitochondrial biogenesis, and its involvement in mitochondrial dynamics. This research not only aids in elucidating the molecular underpinnings of diseases associated with TIMM8B deficiencies but also has potential implications for therapeutic strategies, including gene therapy and targeted drug design aimed at restoring mitochondrial function in affected individuals. Overall, the investigation of TIMM8B through recombinant protein studies is a vital step towards advancing our knowledge of mitochondrial biology and developing innovative treatments for related disorders.
