Analytical Data
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Gene name
TIMM9
- Application
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Alternative Names
Mitochondrial import inner membrane translocase subunit Tim9; TIM9; TIM9_HUMAN; TIM9A; Timm9; TIMM9A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y5J7
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Expression Region
2-89 aa
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AA Sequence
AAQIPESDQ IKQFKEFLGT YNKLTETCFL DCVKDFTTRE VKPEETTCSE HCLQKYLKMT QRISMRFQEY HIQQNEALAA KAGLLGQPR
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Molecular Weight
10.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TIMM9 (Translocase of Inner Mitochondrial Membrane 9) is a crucial component of the mitochondrial import machinery, playing a significant role in transporting proteins into the mitochondria. Mitochondria are vital organelles involved in energy production and cellular metabolism, and their dysfunction is linked to various diseases, including neurodegenerative disorders and metabolic syndromes. The study of TIMM9 and its recombinant protein form has gained attention due to its potential role in understanding mitochondrial biology and pathology. Researchers aim to unravel the mechanism of TIMM9 in protein translocation and its interaction with other mitochondrial proteins. Additionally, TIMM9's potential as a therapeutic target is being explored, as modulating its function could offer novel strategies for alleviating mitochondrial-related diseases. The recombinant TIMM9 protein is utilized in diverse assays to investigate its structure, function, and interactions, providing insights into the broader aspects of mitochondrial dynamics and their implications in health and disease. Understanding TIMM9's role could lead to advancements in treatments for mitochondrial dysfunction, emphasizing the importance of this research within the field of cellular and molecular biology.
