Analytical Data
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Gene name
ZFP42
- Application
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Alternative Names
hREX-1; Reduced Expression 1 Protein; Reduced expression Protein 1; Rex-1; REX1; REX1 transcription factor; Zfp-42; Zfp42; ZFP42 zinc finger Protein; ZFP42_HUMAN; Zinc finger Protein 42 homolog; Zinc finger Protein 754; ZNF754
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96MM3
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Expression Region
1-310 aa
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AA Sequence
MSQQLKKRAKTRHQKGLGGRAPSGAKPRQGKSSQDLQAEIEPVSAVWALCDGYVCYEPGPQALGGDDFSDCYIECVIRGEFSQPILEEDSLFESLEYLKKGSEQQLSQKVFEASSLECSLEYMKKGVKKELPQKIVGENSLEYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARKKPPINKEYDSLSAIACPQSGCTRKLRNRAALRKHLLIHGPRDHVCAECGKAFVESSKLKRHFLVHTGEKPFRCTFEGCGKRFSLDFNLRTHVRIHTGEKRFVCPFQGCNRRFIQSNNLKAHILTHANTNKNEQEGK
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Molecular Weight
61.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZFP42, also known as Rex1, is a zinc finger protein that plays a crucial role in stem cell biology and early embryonic development. It is primarily expressed in embryonic stem cells (ESCs) and is involved in maintaining pluripotency, the ability of a stem cell to differentiate into various cell types. Research has shown that ZFP42 is essential for the self-renewal of ESCs and influences their fate decisions during the differentiation process. Its expression is tightly regulated, and aberrations can lead to impaired stem cell function or contribute to developmental disorders. Recent studies have focused on the mechanisms by which ZFP42 interacts with other transcription factors and chromatin regulators to modulate gene expression. The recombinant production of ZFP42 protein allows for detailed functional assays to elucidate its role in stem cell maintenance and differentiation pathways. Furthermore, understanding the specific interactions and regulatory networks involving ZFP42 may provide insights into regenerative medicine and therapeutic strategies for tissue engineering and stem cell therapy. Research on ZFP42 has significant implications for enhancing the efficiency of stem cell-based therapies and for developing novel approaches to manipulate stem cell behavior in regenerative medicine. As such, ZFP42 represents a key target for further investigation in the field of developmental biology and stem cell research.
