Analytical Data
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基因名
THRAP5
- Application
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别名
Med16; Thrap5; Mediator of RNA polymerase II transcription subunit 16; Mediator complex subunit 16; Thyroid hormone receptor-associated Protein 5; Thyroid hormone receptor-associated Protein complex 95 kDa component; Trap95; Vitamin D3 receptor-interacting Protein complex 92 kDa component; DRIP92
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6PGF3
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表达区间
1-860 aa
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氨基酸序列
MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICFPSTGPCSVWVLLGWQPLPGRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGACPTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCLCGGLWWRVPLSYP
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分子量
121.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
THRAP5 (Thyroid Hormone Receptor Associated Protein 5) is a key protein implicated in the regulation of gene expression and various cellular processes. It is part of the transcriptional co-regulators that interact with nuclear hormone receptors, influencing their ability to modulate target gene activity in response to thyroid hormones. Due to its role in cellular mechanisms such as proliferation, differentiation, and apoptosis, THRAP5 has garnered attention in various fields, including cancer research and metabolic disorders. Studies have shown that alterations in THRAP5 expression can affect tumor progression and response to treatments in different cancers, suggesting its potential as a biomarker or therapeutic target. Therefore, the generation of recombinant THRAP5 proteins is essential for further elucidating its biological functions, interaction partners, and structural characteristics. Utilizing recombinant techniques allows for the production of purified THRAP5 protein, facilitating in vitro studies such as binding assays, functional assays, and structural analyses. This research not only enhances our understanding of THRAP5's role in normal physiological functions but also its implications in pathological conditions, thereby paving the way for novel therapeutic approaches that may leverage THRAP5 modulation in disease contexts.
