Analytical Data
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Gene name
DYNC1H1
- Application
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Alternative Names
DYNC1H1；DHC1；DNCH1；DNCL；Cytoplasmic dynein 1 heavy chain 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14204
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Expression Region
全长
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AA Sequence
full
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DYNC1H1 is a crucial gene encoding the cytoplasmic dynein heavy chain 1, which plays a pivotal role in the retrograde transport of various cellular components along microtubules. Dynein functions as a motor protein, facilitating the movement of organelles, vesicles, and signaling molecules toward the cell nucleus, thus influencing numerous cellular processes, including mitosis, cell differentiation, and neuronal function. Mutations in the DYNC1H1 gene have been linked to several neurodegenerative diseases and developmental disorders, which highlight its importance in maintaining cellular homeostasis. Given the relevance of DYNC1H1 in health and disease, researchers have focused on the study of its recombinant protein to understand its structural and functional properties. By producing and characterizing DYNC1H1 recombinant protein, scientists aim to elucidate the mechanisms underlying dynein function and its interactions with other cellular components. Moreover, this research is essential for exploring potential therapeutic strategies for conditions associated with DYNC1H1 mutations. Understanding how dynein operates at a molecular level could pave the way for innovative treatments targeting the transport dysfunctions seen in various pathologies, ultimately contributing to advancements in regenerative medicine and neurobiology.
