Analytical Data
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Gene name
THEX1
- Application
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Alternative Names
3'-5' exoribonuclease 1. EC:3.1.13.1. 3'-5' exonuclease ERI1. Eri-1 homolog. Histone mRNA 3'-end-specific exoribonuclease. Histone mRNA 3'-exonuclease 1. Protein 3'hExo. HEXO
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IV48
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Expression Region
1-349 aa
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AA Sequence
MEDPQSKEPAGEAVALALLESPRPEGGEEPPRPSPEETQQCKFDGQETKGSKFITSSASDFSDPVYKEIAITNGCINRMSKEELRAKLSEFKLETRGVKDVLKKRLKNYYKKQKLMLKESNFADSYYDYICIIDFEATCEEGNPPEFVHEIIEFPVVLLNTHTLEIEDTFQQYVRPEINTQLSDFCISLTGITQDQVDRADTFPQVLKKVIDWMKLKELGTKYKYSLLTDGSWDMSKFLNIQCQLSRLKYPPFAKKWINIRKSYGNFYKVPRSQTKLTIMLEKLGMDYDGRPHCGLDDSKNIARIAVRMLQDGCELRINEKMHAGQLMSVSSSLPIEGTPPPQMPHFRK
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Molecular Weight
66.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
THEX1 is a recombinant protein that has garnered significant interest in the field of molecular biology due to its role in various cellular processes. It was initially identified as a key player in the regulation of gene expression and has been linked to several important biological functions, including cell differentiation, proliferation, and apoptosis. Research on THEX1 has revealed its involvement in signaling pathways that are critical for maintaining cellular homeostasis and responding to external stimuli. The protein's unique structural features, such as its conserved domains and potential post-translational modifications, make it a target of interest for studies aimed at deciphering the molecular mechanisms underlying its functions. Furthermore, THEX1 has been implicated in various diseases, including certain forms of cancer, where its expression levels and activity can significantly impact tumor progression and response to therapy. Thus, understanding THEX1’s biological role and mechanisms of action not only provides insights into fundamental cellular processes but also opens avenues for potential therapeutic interventions. The use of recombinant technology to produce THEX1 in sufficient quantities has facilitated detailed functional studies, allowing researchers to explore its properties in vitro and in vivo. As such, ongoing research aims to elucidate the precise roles of THEX1 in health and disease, contributing to the broader understanding of protein functions in cellular contexts and their implications in treating diseases associated with dysregulated protein activity.
