Analytical Data
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基因名
CHRM2
- Application
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别名
CHRM2；Muscarinic acetylcholine receptor M2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08172
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表达区间
210-387aa
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氨基酸序列
SRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTR
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分子量
23.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CHRM2, a gene encoding the muscarinic acetylcholine receptor M2, plays a crucial role in various physiological processes, including modulation of neurotransmitter release and regulation of cardiovascular functions. Research has shown that CHRM2 is involved in cognitive functions and has been associated with several neuropsychiatric disorders, such as schizophrenia and Alzheimer's disease. The receptor's activation influences intracellular signaling pathways, making it a target for potential therapeutic interventions. The study of recombinant CHRM2 protein is essential for understanding the receptor's structure-function relationship and developing drugs that can selectively modulate its activity. By producing recombinant CHRM2 in various expression systems, researchers aim to investigate its pharmacological properties and interactions with ligands. This research not only contributes to basic science but also has implications for designing novel treatments for diseases linked to CHRM2 dysregulation. Furthermore, the successful characterization and manipulation of this protein may open up avenues for advanced therapeutic strategies in the field of neurology and psychiatry.
