Analytical Data
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基因名
TERF2IP
- Application
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别名
TERF2IP；KARS；KIAA0070；Lysine--tRNA ligase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NYB0
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表达区间
1-399aa
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氨基酸序列
MAEAMDLGKDPNGPTHSSTLFVRDDGSSMSFYVRPSPAKRRLSTLILHGG GTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVERNERLELEAYR LGPASAADTGSEAKPGALAEGAAEPEPQRHAGRIAFTDADDVAILTYVKE NARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGDA PVSPSSQKLKRKAEEDPEAADSGEPQNKRTPDLPEEEYVKEEIQENEEAV KKMLVEATREFEEVVVDESPPDFEIHITMCDDDPPTPEEDSETQPDEEEE EEEEKVSQPEVGAAIKIIRQLMEKFNLDLSTVTQAFLKNSGELEATSAFL ASGQRADGYPIWSRQDDIDLQKDDEDTREALVKKFGAQNVARRIEFRKK
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TERF2IP, also known as TEP1 or TRF2-interacting protein, is a critical component involved in maintaining telomere integrity and regulating cellular senescence. Its primary function centers around the shelterin complex, which protects telomeric DNA from damage and prevents it from being recognized as DNA double-strand breaks. Research has indicated that TERF2IP plays a significant role in the stabilization of telomeres, thereby influencing gene expression and cellular aging processes. The dysfunction or downregulation of TERF2IP is often associated with various age-related diseases and cancers, highlighting its importance in both aging biology and tumorigenesis. The study of TERF2IP recombinant protein offers valuable insights into its functional mechanisms and interactions within the shelterin complex, enabling researchers to explore potential therapeutic targets for diseases linked to telomere dysfunction. Understanding the protein's structure and interactions can reveal how it contributes to genomic stability and may lead to innovative strategies for cancer treatment and aging interventions. As research continues to uncover the multifaceted roles of TERF2IP, it presents a promising avenue for advancing our knowledge of telomere biology and its implications in health and disease.
