Analytical Data
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基因名
TGIF
- Application
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别名
CSIF; Cytokine synthesis inhibitory factor; GVHDS; IL 10; IL-10; IL10; IL10_HUMAN; IL10A; Interleukin 10; Interleukin-10; MGC126450; MGC126451; T-cell growth inhibitory factor; TGIF
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P22301
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表达区间
19-178 aa
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氨基酸序列
SPGQGTQSEN SCTHFPGNLP NMLRDLRDAF SRVKTFFQMK DQLDNLLLKE SLLEDFKGYL GCQALSEMIQ FYLEEVMPQA ENQDPDIKAH VNSLGENLKT LRLRLRRCHR FLPCENKSKA VEQVKNAFNK LQEKGIYKAM SEFDIFINYI EAYMTMKIRN
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分子量
18.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TGIF (Thyroid hormone receptor interactor 1) is a crucial protein implicated in various biological processes, including development and cellular signaling pathways. Research into TGIF began due to its role as a transcriptional repressor that interacts with thyroid hormone receptors, influencing gene expression and regulation. Additionally, TGIF has been associated with developmental disorders such as holoprosencephaly, a condition arising from improper embryonic development. The study of TGIF's structure and function is vital for understanding its mechanism of action, particularly its involvement in genetic pathways and its potential implications in diseases, including cancers. Given the multifunctional nature of TGIF, scientists are focusing on its reorganization and interaction with other molecular partners to unveil therapeutic targets and strategies. Furthermore, elucidating TGIF’s structural features can provide insights into its functional role, contributing to the broader understanding of gene regulation and developmental biology. As such, the ongoing research on TGIF protein not only aims to clarify these intricate biological processes but also seeks to explore novel avenues for medical interventions in TGIF-related conditions.
