Analytical Data
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基因名
TRH
- Application
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别名
TRH；Pro-thyrotropin-releasing hormone
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P20396
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表达区间
1-242aa
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氨基酸序列
MPGPWLLLALALTLNLTGVPGGRAQPEAAQQEAVTAAEHPGLDDFLRQVE RLLFLRENIQRLQGDQGEHSASQIFQSDWLSKRQHPGKREEEEEEGVEEE EEEEGGAVGPHKRQHPGRREDEASWSVDVTQHKRQHPGRRSPWLAYAVPK RQHPGRRLADPKAQRSWEEEEEEEEREEDLMPEKRQHPGKRALGGPCGPQ GAYGQAGLLLGLLDDLSRSQGAEEKRQHPGRRAAWVREPLEE
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TRH (Thyrotropin-Releasing Hormone) is a tripeptide that plays a crucial role in the regulation of thyroid function and overall endocrine system activity. Research on recombinant TRH proteins has gained prominence due to their potential therapeutic applications in treating various disorders, including hypothyroidism and certain mood disorders. Traditionally, TRH was extracted from animal sources, but with advancements in biotechnology, researchers have focused on producing recombinant TRH through methods such as recombinant DNA technology. This approach not only ensures a more consistent and abundant supply of the hormone but also allows for modifications that could enhance its stability and efficacy. Moreover, understanding the structure-function relationship of TRH through recombinant methods allows scientists to explore its interactions with specific receptors, paving the way for novel drug development. The growing interest in TRH also stems from its role in the central nervous system, where it influences aspects of behavior and stress response. As research continues, the production of recombinant TRH promises to unlock new insights into its physiological roles and therapeutic potential, potentially addressing unmet medical needs in various fields, including endocrinology and psychiatry.
