Analytical Data
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基因名
CNR2
- Application
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别名
CNR2；CB2A；CB2B；Cannabinoid receptor 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P34972
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表达区间
1-360aa
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氨基酸序列
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALE NVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGV DSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRA LVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAF LFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLV LAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWP DSRDLDLSDC
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分子量
66 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CNR2, also known as the cannabinoid receptor type 2, is a G protein-coupled receptor that plays a crucial role in the endocannabinoid system, which regulates various physiological processes, including pain sensation, inflammation, and immune response. Unlike its counterpart CNR1, which is predominantly expressed in the brain, CNR2 is primarily found in peripheral tissues, suggesting its significant involvement in immune modulation and potential therapeutic applications. Given the increasing interest in cannabinoids for therapeutic purposes, particularly in the context of chronic pain and neurodegenerative diseases, research on CNR2 and its recombinant proteins has gained momentum. Recombinant CNR2 proteins are essential for elucidating the receptor's structure, function, and signaling mechanisms, providing insights into ligand-receptor interactions, and facilitating the development of selective CNR2 agonists or antagonists. Such studies may pave the way for novel treatments targeting CNR2 in various pathologies, including autoimmune disorders and inflammatory diseases. The production and characterization of recombinant CNR2 proteins can also contribute to the understanding of receptor pharmacology and the potential for drug discovery, establishing CNR2 as a promising target in the pharmacological landscape.
