Analytical Data
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Gene name
TDRKH
- Application
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Alternative Names
2700091C21Rik; Putative RNA binding Protein; RGD1311196; RP11-98D18.8; TDRD2; TDRD7; Tdrkh; TDRKH_HUMAN; Tudor and KH domain containing; Tudor and KH domain-containing Protein; tudor domain containing 2; Tudor domain-containing Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y2W6
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Expression Region
1-561 aa
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AA Sequence
MSTERTSWTS LSTIQKIALG LGIPASATVA YILYRRYRES REERLTFVGE DDIEIEMRVP QEAVKLIIGR QGANIKQLRK QTGARIDVDT EDVGDERVLL ISGFPVQVCK AKAAIHQILT ENTPVSEQLS VPQRSVGRII GRGGETIRSI CKASGAKITC DKESEGTLLL SRLIKISGTQ KEVAAAKHLI LEKVSEDEEL RKRIAHSAET RVPRKQPISV RREDMTEPGG AGEPALWKNT SSSMEPTAPL VTPPPKGGGD MAVVVSKEGS WEKPSDDSFQ KSEAQAIPEM PMFEIPSPDF SFHADEYLEV YVSASEHPNH FWIQIVGSRS LQLDKLVNEM TQHYENSVPE DLTVHVGDIV AAPLPTNGSW YRARVLGTLE NGNLDLYFVD FGDNGDCPLK DLRALRSDFL SLPFQAIECS LARIAPSGDQ WEEEALDEFD RLTHCADWKP LVAKISSYVQ TGISTWPKIY LYDTSNGKKL DIGLELVHKG YAIELPEDIE ENRAVPDMLK DMATETDASL STLLTETKKS SGEITHTLSC LSLSEAASMS GDDNLEDDYL L
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Molecular Weight
62.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TDRKH (Tudor Domain Containing Protein) is a critical protein implicated in various cellular processes, particularly in RNA regulation and gene silencing. Research into TDRKH has gained momentum due to its role in the biogenesis and functionality of small RNA molecules, especially in the context of germline development and stem cell maintenance. The protein features multiple Tudor domains, which are known to mediate protein-protein and protein-RNA interactions, suggesting its involvement in assembling ribonucleoprotein complexes. TDRKH is also recognized for facilitating the recruitment of Argonaute proteins, which are essential for RNA interference pathways. Dysregulation or mutation of TDRKH has been associated with various diseases, including cancer, making it a potential biomarker or therapeutic target. Additionally, the understanding of TDRKH’s structure-function relationship can provide insights into the broader mechanisms of RNA-mediated regulatory networks. Consequently, the study of recombinant TDRKH proteins has become significant in elucidating these mechanisms. Researchers have focused on producing and characterizing recombinant TDRKH proteins to investigate their biochemical properties, interactions with small RNAs, and contributions to gene silencing pathways. This research is particularly important not only for understanding fundamental biological processes but also for developing innovative strategies for therapeutic interventions. Thus, investigating recombinant TDRKH proteins represents an important frontier in molecular biology with implications in developmental biology and disease treatment.
