Analytical Data
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基因名
TDRKH
- Application
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别名
2700091C21Rik; Putative RNA binding Protein; RGD1311196; RP11-98D18.8; TDRD2; TDRD7; Tdrkh; TDRKH_HUMAN; Tudor and KH domain containing; Tudor and KH domain-containing Protein; tudor domain containing 2; Tudor domain-containing Protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y2W6
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表达区间
1-561 aa
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氨基酸序列
MSTERTSWTS LSTIQKIALG LGIPASATVA YILYRRYRES REERLTFVGE DDIEIEMRVP QEAVKLIIGR QGANIKQLRK QTGARIDVDT EDVGDERVLL ISGFPVQVCK AKAAIHQILT ENTPVSEQLS VPQRSVGRII GRGGETIRSI CKASGAKITC DKESEGTLLL SRLIKISGTQ KEVAAAKHLI LEKVSEDEEL RKRIAHSAET RVPRKQPISV RREDMTEPGG AGEPALWKNT SSSMEPTAPL VTPPPKGGGD MAVVVSKEGS WEKPSDDSFQ KSEAQAIPEM PMFEIPSPDF SFHADEYLEV YVSASEHPNH FWIQIVGSRS LQLDKLVNEM TQHYENSVPE DLTVHVGDIV AAPLPTNGSW YRARVLGTLE NGNLDLYFVD FGDNGDCPLK DLRALRSDFL SLPFQAIECS LARIAPSGDQ WEEEALDEFD RLTHCADWKP LVAKISSYVQ TGISTWPKIY LYDTSNGKKL DIGLELVHKG YAIELPEDIE ENRAVPDMLK DMATETDASL STLLTETKKS SGEITHTLSC LSLSEAASMS GDDNLEDDYL L
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分子量
62.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TDRKH (Tudor Domain Containing Protein) is a critical protein implicated in various cellular processes, particularly in RNA regulation and gene silencing. Research into TDRKH has gained momentum due to its role in the biogenesis and functionality of small RNA molecules, especially in the context of germline development and stem cell maintenance. The protein features multiple Tudor domains, which are known to mediate protein-protein and protein-RNA interactions, suggesting its involvement in assembling ribonucleoprotein complexes. TDRKH is also recognized for facilitating the recruitment of Argonaute proteins, which are essential for RNA interference pathways. Dysregulation or mutation of TDRKH has been associated with various diseases, including cancer, making it a potential biomarker or therapeutic target. Additionally, the understanding of TDRKH’s structure-function relationship can provide insights into the broader mechanisms of RNA-mediated regulatory networks. Consequently, the study of recombinant TDRKH proteins has become significant in elucidating these mechanisms. Researchers have focused on producing and characterizing recombinant TDRKH proteins to investigate their biochemical properties, interactions with small RNAs, and contributions to gene silencing pathways. This research is particularly important not only for understanding fundamental biological processes but also for developing innovative strategies for therapeutic interventions. Thus, investigating recombinant TDRKH proteins represents an important frontier in molecular biology with implications in developmental biology and disease treatment.
