Analytical Data
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Gene name
MAOB
- Application
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Alternative Names
MAOB；Amine oxidase [flavin-containing] B
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P27338
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Expression Region
2-489aa
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AA Sequence
SNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSV
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Molecular Weight
59.3kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of recombinant MAOB (Monoamine Oxidase B) proteins has garnered considerable attention in the fields of neurobiology and pharmacology due to their critical role in the metabolism of neurotransmitters, particularly dopamine. MAOB is an enzyme primarily found in the brain and is responsible for the oxidative deamination of monoamines, which is essential for regulating mood and cognitive functions. Overactivity of MAOB has been implicated in a variety of neurodegenerative diseases, including Parkinson's disease and Alzheimer's disease, where excess dopamine degradation can lead to neurotoxicity and synaptic dysfunction. The ability to generate recombinant MAOB proteins allows researchers to explore the enzyme's structure-function relationships, develop specific inhibitors, and investigate its potential as a therapeutic target. By producing these proteins in bacterial or eukaryotic systems, scientists can obtain large quantities of MAOB for biochemical assays, structural studies, and drug screening. Furthermore, understanding the enzymatic mechanisms and regulation of MAOB is paramount for developing MAOB inhibitors, which are already used as antidepressants and are being evaluated for their neuroprotective properties. The research surrounding recombinant MAOB not only contributes to the understanding of neurochemical processes but also holds promise for advancing therapeutic strategies aimed at treating various psychiatric and neurodegenerative disorders.
