Analytical Data
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基因名
DUX1
- Application
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别名
DUX1Double homeobox protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O43812
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表达区间
1-170aa
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氨基酸序列
MALLTALDDT LPEEAQGPGR RMILLSTPSQ SDALRACFER NLYPGIATKE ELAQGIDIPE PRVQIWFQNE RSCQLRQHRR QSRPWPGRRD PQKGRRKRTA ITGSQTALLL RAFEKDRFPG IAAREELARE TGLPESRIQI WFQNRRARHR GQSGRAPTQA SIRCNAAPIG
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分子量
19.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DUX1 (Double Homeobox 1) is a transcription factor that plays a crucial role in early embryonic development and is involved in the regulation of pluripotency in embryonic stem cells. Its expression is tightly controlled, as abnormal levels can lead to various developmental disorders and contribute to tumorigenesis, particularly in certain cancers such as prostate cancer and leukemia. The study of DUX1 has gained significant attention due to its potential implications in regenerative medicine and cancer therapy. Researchers have focused on understanding its functional mechanisms and pathways, particularly how DUX1 mediates gene expression programs that govern cell fate decisions. Recombinant DUX1 protein is increasingly used in laboratory settings to elucidate its specific interactions with DNA and other nuclear proteins, paving the way for the development of targeted therapeutic strategies. The production of DUX1 as a recombinant protein allows for detailed structural and functional studies, enhancing our understanding of its role in stem cell biology and cancer. This research not only aims to uncover the intricate regulatory networks in which DUX1 operates but also seeks to identify novel biomarkers and therapeutic targets that could lead to improved outcomes in diseases associated with DUX1 dysregulation.
