Analytical Data
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基因名
DOCK3
- Application
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别名
DOCK3；KIAA0299；MOCA；Dedicator of cytokinesis Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8IZD9
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DOCK3 (Dedicator of Cytokinesis 3) is a member of the DOCK family of proteins, which are guanine nucleotide exchange factors (GEFs) that facilitate the activation of Rho GTPases, thereby playing a crucial role in various cellular processes such as cytoskeleton organization, cell migration, and neuronal development. Recent studies have indicated that DOCK3 is involved in important signaling pathways related to neuronal survival and differentiation, making it a significant focus in neurobiology and cancer research. The expression of DOCK3 has been found to be dysregulated in several malignancies, suggesting a potential role in tumor progression and metastasis. Moreover, its involvement in modulating neuronal functions highlights its importance in neurodegenerative diseases, including Alzheimer's and Parkinson's disease. As a result, the study of recombinant DOCK3 protein has gained attention for its potential applications in therapeutic interventions and as a research tool to unravel the complex mechanisms underlying cell signaling and disease pathology. Understanding the structure and function of DOCK3 could pave the way for novel strategies to manipulate Rho GTPase activity, aiding in the development of targeted therapies for both cancer and neurodegenerative disorders. Thus, the functional characterization and analysis of DOCK3 as a recombinant protein are pivotal in elucidating its biological roles and therapeutic potential.
