Analytical Data
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Gene name
DUSP8
- Application
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Alternative Names
C11orf81; Chromosome 11 open reading frame 81 ; Deubiquitinating enzyme 8; Dual Specificity Phosphatase 8; Dual specificity phosphatase M3/6; Dual specificity protein phosphatase 8; Dual specificity protein phosphatase hVH 5; Dual specificity protein phosphatase hVH-5; DUS8; DUS8_HUMAN; DUSP8; EC 3.1.3.16; EC 3.1.3.48; FLJ42476
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13202
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Expression Region
2-109aa
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AA Sequence
AGDRLPRKVMDAKKLASLLRGGPGGPLVIDSRSFVEYNSWHVLSSVNICCSKLVKRRLQQGKVTIAELIQPAARSQVEATEPQDVVVYDQSTRDASVLAADSFLSILL
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Molecular Weight
37.62 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DUSP8 (Dual Specificity Phosphatase 8) is a member of the dual specificity phosphatase family, known for its ability to dephosphorylate both tyrosine and serine/threonine residues, playing a crucial role in regulating various cellular signaling pathways. Its involvement in numerous biological processes, including cell proliferation, differentiation, and apoptosis, has made DUSP8 a significant focus in cancer research and other diseases. Dysregulation of DUSP8 has been implicated in the progression of several malignancies, highlighting the need for a deeper understanding of its functions and mechanisms. The study of recombinant DUSP8 protein allows researchers to gain insights into its enzymatic properties, interaction with substrates, and potential as a therapeutic target. By utilizing techniques such as protein expression, purification, and functional assays, researchers aim to elucidate the precise biological roles of DUSP8 and explore its potential implications in disease modulation and treatment strategies. This research not only advances our comprehension of DUSP8's physiological roles but also contributes to broader efforts to develop targeted therapies that could manipulate phosphatase activity for clinical benefits.
