Analytical Data
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Gene name
YIF1A
- Application
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Alternative Names
YIF1A; 54TM; HYIF1P; YIF1; Protein YIF1A; 54TMp; YIP1-interacting factor homolog A
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95070
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Expression Region
1-293 aa
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AA Sequence
MAYHSGYGAHGSKHRARAAPDPPPLFDDTSGGYSSQPGGYPATGADVAFSVNHLLGDPMANVAMAYGSSIASHGKDMVHKELHRFVSVSKLKYFFAVDTAYVAKKLGLLVFPYTHQNWEVQYSRDAPLPPRQDLNAPDLYIPTMAFITYVLLAGMALGIQKRFSPEVLGLCASTALVWVVMEVLALLLGLYLATVRSDLSTFHLLAYSGYKYVGMILSVLTGLLFGSDGYYVALAWTSSALMYFIVRSLRTAALGPDSMGGPVPRQRLQLYLTLGAAAFQPLIIYWLTFHLVR
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Molecular Weight
58.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
YIF1A, or Yip1 domain family member 1A, is a significant protein involved in various cellular processes, particularly in the context of endoplasmic reticulum (ER) and Golgi membrane trafficking. Research surrounding YIF1A has gained momentum due to its integral role in maintaining the structural integrity and function of the secretory pathway in eukaryotic cells. Dysfunction of YIF1A has been implicated in several diseases, including neurodegenerative disorders and certain cancers, where its misregulation can lead to impaired protein transport and accumulation of misfolded proteins. Studies have sought to elucidate the mechanistic functions of YIF1A, revealing its interactions with other proteins involved in vesicular transport and its potential regulatory effects on intracellular signaling pathways. The generation of recombinant YIF1A has become a crucial tool for researchers aiming to explore its biological functions and to develop therapeutic strategies targeting YIF1A-related pathways. This recombinant protein can be used in various assays, including cell-free translation systems and in vitro binding studies, to investigate the dynamics of YIF1A and its role in membrane dynamics, protein sorting, and cellular stress responses. Given the growing interest in the pathophysiological implications of YIF1A, continued research into the characterization and applications of this recombinant protein could provide deeper insights into cellular homeostasis and the development of novel therapeutic interventions.
