Analytical Data
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Gene name
TBL2
- Application
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Alternative Names
TBL2; WBSCR13; UNQ563/PRO1125Transducin beta-like protein 2; WS beta-transducin repeats protein; WS-betaTRP; Williams-Beuren syndrome chromosomal region 13 protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y4P3
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Expression Region
1-447 aa
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AA Sequence
MELSQMSELM GLSVLLGLLA LMATAAVARG WLRAGEERSG RPACQKANGF PPDKSSGSKK QKQYQRIRKE KPQQHNFTHR LLAAALKSHS GNISCMDFSS NGKYLATCAD DRTIRIWSTK DFLQREHRSM RANVELDHAT LVRFSPDCRA FIVWLANGDT LRVFKMTKRE DGGYTFTATP EDFPKKHKAP VIDIGIANTG KFIMTASSDT TVLIWSLKGQ VLSTINTNQM NNTHAAVSPC GRFVASCGFT PDVKVWEVCF GKKGEFQEVV RAFELKGHSA AVHSFAFSND SRRMASVSKD GTWKLWDTDV EYKKKQDPYL LKTGRFEEAA GAAPCRLALS PNAQVLALAS GSSIHLYNTR RGEKEECFER VHGECIANLS FDITGRFLAS CGDRAVRLFH NTPGHRAMVE EMQGHLKRAS NESTRQRLQQ QLTQAQETLK SLGALKK
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Molecular Weight
49.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBL2, a member of the TBL (TGF-beta receptor associated protein with a coiled-coil domain) family, has emerged as a significant player in cellular signaling and developmental processes. Research into TBL2's function is driven by its role in modulating pathways such as the TGF-beta signaling cascade, which is crucial for cell proliferation, differentiation, and apoptosis. Dysregulation of TBL2 has been implicated in various diseases, including cancer, making it a target for therapeutic intervention. Recent studies have focused on characterizing the protein's structure and understanding its interaction with other signaling molecules. Additionally, the recombinant production of TBL2 protein has enabled researchers to investigate its biochemical properties and biological functions in detail. This recombinant approach has facilitated high-yield production, allowing for extensive study of TBL2's functional domains and their relevance in health and disease. The insights gained from these studies could pave the way for novel strategies in the treatment of TGF-beta related disorders, thereby highlighting the importance of TBL2 as both a biological marker and a potential therapeutic target.
