Analytical Data
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基因名
TBL2
- Application
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别名
TBL2; WBSCR13; UNQ563/PRO1125Transducin beta-like protein 2; WS beta-transducin repeats protein; WS-betaTRP; Williams-Beuren syndrome chromosomal region 13 protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y4P3
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表达区间
1-447 aa
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氨基酸序列
MELSQMSELM GLSVLLGLLA LMATAAVARG WLRAGEERSG RPACQKANGF PPDKSSGSKK QKQYQRIRKE KPQQHNFTHR LLAAALKSHS GNISCMDFSS NGKYLATCAD DRTIRIWSTK DFLQREHRSM RANVELDHAT LVRFSPDCRA FIVWLANGDT LRVFKMTKRE DGGYTFTATP EDFPKKHKAP VIDIGIANTG KFIMTASSDT TVLIWSLKGQ VLSTINTNQM NNTHAAVSPC GRFVASCGFT PDVKVWEVCF GKKGEFQEVV RAFELKGHSA AVHSFAFSND SRRMASVSKD GTWKLWDTDV EYKKKQDPYL LKTGRFEEAA GAAPCRLALS PNAQVLALAS GSSIHLYNTR RGEKEECFER VHGECIANLS FDITGRFLAS CGDRAVRLFH NTPGHRAMVE EMQGHLKRAS NESTRQRLQQ QLTQAQETLK SLGALKK
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分子量
49.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBL2, a member of the TBL (TGF-beta receptor associated protein with a coiled-coil domain) family, has emerged as a significant player in cellular signaling and developmental processes. Research into TBL2's function is driven by its role in modulating pathways such as the TGF-beta signaling cascade, which is crucial for cell proliferation, differentiation, and apoptosis. Dysregulation of TBL2 has been implicated in various diseases, including cancer, making it a target for therapeutic intervention. Recent studies have focused on characterizing the protein's structure and understanding its interaction with other signaling molecules. Additionally, the recombinant production of TBL2 protein has enabled researchers to investigate its biochemical properties and biological functions in detail. This recombinant approach has facilitated high-yield production, allowing for extensive study of TBL2's functional domains and their relevance in health and disease. The insights gained from these studies could pave the way for novel strategies in the treatment of TGF-beta related disorders, thereby highlighting the importance of TBL2 as both a biological marker and a potential therapeutic target.
