Analytical Data
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Gene name
TBL1Y
- Application
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Alternative Names
F-box-like/WD repeat-containing protein TBL1Y. Transducin beta-like protein 1Y. Transducin-beta-like protein 1. Y-linked
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BQ87
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Expression Region
1-522 aa
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AA Sequence
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPDVVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQGTGGIFEVCWNARGDKVGASASDGSVCVLDL
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Molecular Weight
57.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBL1Y, or Tazarotene-induced gene 1, is a protein encoded by the TBL1Y gene located on the Y chromosome, playing a significant role in various biological processes, including spermatogenesis and embryonic development. The study of TBL1Y is particularly pertinent given its association with male fertility and potential implications in sex determination and reproductive health. Research indicates that TBL1Y may function as a transcriptional coactivator involved in the regulation of target genes critical for testis development and function. The significance of TBL1Y extends to the investigation of Y chromosome-linked disorders, such as male infertility syndromes, where mutations or deletions in TBL1Y can lead to adverse reproductive outcomes. Furthermore, TBL1Y's involvement in signaling pathways and cellular mechanisms enhances its relevance in understanding broader biological phenomena, including cancer progression and resistance to therapy in males. As a result, the exploration of TBL1Y not only contributes to the fields of genetics and reproductive biology but also opens avenues for potential therapeutic interventions aimed at addressing male infertility and associated conditions. Continuing research on TBL1Y is essential for elucidating its precise functions, regulatory mechanisms, and potential clinical applications.
