Analytical Data
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基因名
AAP
- Application
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别名
AAP；PSA；Puromycin-sensitive aminopeptidase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08697
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表达区间
40-491aa
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氨基酸序列
N QEQVSPLTLL KLGNQEPGGQ TALKSPPGVC SRDPTPEQTH RLARAMMAFT ADLFSLVAQT STCPNLILSP LSVALALSHL ALGAQNHTLQ RLQQVLHAGS GPCLPHLLSR LCQDLGPGAF RLAARMYLQK GFPIKEDFLE QSEQLFGAKP VSLTGKQEDD LANINQWVKE ATEGKIQEFL SGLPEDTVLL LLNAIHFQGF WRNKFDPSLT QRDSFHLDEQ FTVPVEMMQA RTYPLRWFLL EQPEIQVAHF PFKNNMSFVV LVPTHFEWNV SQVLANLSWD TLHPPLVWER PTKVRLPKLY LKHQMDLVAT LSQLGLQELF QAPDLRGISE QSLVVSGVQH QSTLELSEVG VEAAAATSIA MSRMSLSSFS VNRPFLFFIF EDTTGLPLFV GSVRNPNPSA PRELKEQQDS PGNKDFLQSL KGFPRGDKLF GPDLKLVPPM EEDYPQFGSP K
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
AAP (Adenylate Cyclase-Activating Polypeptide) is a significant member of the vasoactive intestinal peptide (VIP) family, known for its diverse biological roles, including modulation of neuronal activity, neuroprotection, and influence on endocrine functions. Research into AAP has gained momentum due to its involvement in various physiological and pathological processes, such as stress response, circadian rhythm regulation, and inflammation. AAP’s receptor interactions lead to activation of intracellular signaling pathways, notably the cyclic AMP (cAMP) pathway, which plays a crucial role in cell signaling and function. Given its widespread effects on multiple organ systems and its potential therapeutic implications, AAP has become a target for drug development in treating conditions like neurodegenerative diseases, mood disorders, and metabolic syndrome. Investigations into the structure and function of recombinantly expressed AAP proteins have provided insights into their mechanisms and allowed for the development of novel therapeutics. Furthermore, the ability to produce AAP in a recombinant form has facilitated detailed studies into its post-translational modifications and stability, enhancing our understanding of its biological activity and therapeutic potential. This burgeoning field underscores the importance of AAP research in uncovering new avenues for clinical intervention and expanding our knowledge of neuropeptide biology.
