Analytical Data
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基因名
TBL1XR1
- Application
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别名
C21; DC42; F box like/WD repeat containing protein TBL1XR1; F-box-like/WD repeat-containing protein TBL1XR1; FLJ12894; IRA1; Nuclear receptor corepressor/HDAC3 complex subunit; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1 related protein 1; TBL1-related protein 1; TBL1R_HUMAN; TBL1XR1; TBLR1; Transducin (beta) like 1 X linked receptor 1; Transducin beta like 1X related protein 1; Transducin beta-like 1X-related protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BZK7
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表达区间
2-514 aa
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氨基酸序列
SISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI SIIQKGLQYV EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR DKLAQQQAAA AAAAAAAASQ QGSAKNGENT ANGEENGAHT IANNHTDMME VDGDVEIPPN KAVVLRGHES EVFICAWNPV SDLLASGSGD STARIWNLSE NSTSGSTQLV LRHCIREGGQ DVPSNKDVTS LDWNSEGTLL ATGSYDGFAR IWTKDGNLAS TLGQHKGPIF ALKWNKKGNF ILSAGVDKTT IIWDAHTGEA KQQFPFHSAP ALDVDWQSNN TFASCSTDMC IHVCKLGQDR PIKTFQGHTN EVNAIKWDPT GNLLASCSDD MTLKIWSMKQ DNCVHDLQAH NKEIYTIKWS PTGPGTNNPN ANLMLASASF DSTVRLWDVD RGICIHTLTK HQEPVYSVAF SPDGRYLASG SFDKCVHIWN TQTGALVHSY RGTGGIFEVC WNAAGDKVGA SASDGSVCVL DLRK
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分子量
55.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBL1XR1, or TBL1 X-Linked Regulator 1, is a crucial protein involved in various cellular processes, including gene regulation and signal transduction. Its role as a co-regulator in the Wnt signaling pathway has garnered substantial interest, as aberrations in this pathway are closely linked to various cancers and developmental disorders. Research on TBL1XR1 has indicated its involvement in the regulation of transcription factors, thus influencing cellular responses to external stimuli. Moreover, TBL1XR1 interacts with other proteins, such as nuclear receptor co-repressors, which further highlights its importance in modulating gene expression. The protein also plays a role in cellular differentiation and proliferation, making it a potential target for therapeutic interventions in diseases characterized by dysfunctional signaling pathways. Given the complexity of TBL1XR1's functions and its implications in oncogenesis and developmental biology, researchers are keen to explore its structure, binding interactions, and regulatory mechanisms. This ongoing research aims to elucidate the precise roles of TBL1XR1 in health and disease, paving the way for novel strategies in disease prevention and treatment. As such, TBL1XR1 is positioned as a promising subject of study within molecular biology and biomedicine, with the potential to unlock new avenues for understanding and tackling complex diseases.
