Analytical Data
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Gene name
DUSP15
- Application
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Alternative Names
bA243J16.5; Chromosome 20 open reading frame 57; Dual specificity phosphatase 15; Dual specificity phosphatase like 15; Dual specificity protein phosphatase 15; DUS15_HUMAN; DUSP15; EC 3.1.3.16; EC 3.1.3.48; FLJ20645
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H1R2
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Expression Region
1-235aa
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AA Sequence
MGNGMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKLRRQLEERFGESPFRDEEELRALLPLCKRCRQGSATSASSAGPHSAASEGTLQRLVPRTPREAHRPLPLLARVKQTFSCLPRCLSRKGGK
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Molecular Weight
52.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DUSP15 (Dual Specificity Phosphatase 15) is a member of the dual specificity phosphatase family, which is known for its ability to dephosphorylate both serine/threonine and tyrosine residues in proteins. The expression and activity of DUSP15 have been implicated in various cellular processes, including cell growth, differentiation, and apoptosis, making it a crucial player in maintaining cellular homeostasis. Research has shown that DUSP15 is involved in modulating key signaling pathways, such as the mitogen-activated protein kinase (MAPK) pathway, which is essential for cellular responses to environmental stimuli. Dysregulation of DUSP15 has been linked to various diseases, including cancer, where abnormal phosphatase activity can lead to uncontrolled proliferation and survival of malignant cells. Given its significant role in these critical cellular mechanisms, the recombinant expression of DUSP15 is essential for both functional studies and potential therapeutic applications. By producing DUSP15 as a recombinant protein, researchers aim to investigate its enzymatic properties, substrate specificity, and regulatory mechanisms in detail. Understanding the precise roles of DUSP15 in cellular signaling may provide insights into its contribution to disease pathology and identify potential targets for therapeutic intervention, particularly in cancer treatment strategies. As the understanding of DUSP15 continues to evolve, it underscores the importance of phosphatases in cell signaling networks and their potential as biomarkers or therapeutic targets in various diseases.
