Analytical Data
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基因名
DUSP15
- Application
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别名
bA243J16.5; Chromosome 20 open reading frame 57; Dual specificity phosphatase 15; Dual specificity phosphatase like 15; Dual specificity protein phosphatase 15; DUS15_HUMAN; DUSP15; EC 3.1.3.16; EC 3.1.3.48; FLJ20645
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H1R2
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表达区间
1-235aa
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氨基酸序列
MGNGMTKVLPGLYLGNFIDAKDLDQLGRNKITHIISIHESPQPLLQDITYLRIPVADTPEVPIKKHFKECINFIHCCRLNGGNCLVHCFAGISRSTTIVTAYVMTVTGLGWRDVLEAIKATRPIANPNPGFRQQLEEFGWASSQKLRRQLEERFGESPFRDEEELRALLPLCKRCRQGSATSASSAGPHSAASEGTLQRLVPRTPREAHRPLPLLARVKQTFSCLPRCLSRKGGK
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分子量
52.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DUSP15 (Dual Specificity Phosphatase 15) is a member of the dual specificity phosphatase family, which is known for its ability to dephosphorylate both serine/threonine and tyrosine residues in proteins. The expression and activity of DUSP15 have been implicated in various cellular processes, including cell growth, differentiation, and apoptosis, making it a crucial player in maintaining cellular homeostasis. Research has shown that DUSP15 is involved in modulating key signaling pathways, such as the mitogen-activated protein kinase (MAPK) pathway, which is essential for cellular responses to environmental stimuli. Dysregulation of DUSP15 has been linked to various diseases, including cancer, where abnormal phosphatase activity can lead to uncontrolled proliferation and survival of malignant cells. Given its significant role in these critical cellular mechanisms, the recombinant expression of DUSP15 is essential for both functional studies and potential therapeutic applications. By producing DUSP15 as a recombinant protein, researchers aim to investigate its enzymatic properties, substrate specificity, and regulatory mechanisms in detail. Understanding the precise roles of DUSP15 in cellular signaling may provide insights into its contribution to disease pathology and identify potential targets for therapeutic intervention, particularly in cancer treatment strategies. As the understanding of DUSP15 continues to evolve, it underscores the importance of phosphatases in cell signaling networks and their potential as biomarkers or therapeutic targets in various diseases.
