Cat: PAX2000-12586

Recombinant Human XRCC6BP1 Protein,GST

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Analytical Data

  • Gene name

    XRCC6BP1

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    ATP23; KUB3; XRCC6BP1Mitochondrial inner membrane protease ATP23 homolog; EC 3.4.24.-; Ku70-binding Protein 3; XRCC6-binding Protein 1

  • Species

    Human

  • Source

    E. coli

  • Tag

    GST-tag at N-terminal

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9Y6H3

  • Expression Region

    1-246 aa

  • AA Sequence

    MAGAPDERRRGPAAGEQLQQQHVSCQVFPERLAQGNPQQGFFSSFFTSNQKCQLRLLKTLETNPYVKLLLDAMKHSGCAVNKDRHFSCEDCNGNVSGGFDASTSQIVLCQNNIHNQAHMNRVVTHELIHAFDHCRAHVDWFTNIRHLACSEVRAANLSGDCSLVNEIFRLHFGLKQHHQTCVRDRATLSILAVRNISKEVAKKAVDEVFESCFNDHEPFGRIPHNKTYARYAHRDFENRDRYYSNI

  • Molecular Weight

    52.69 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

XRCC6BP1, also known as Ku86, is a critical component of the DNA repair machinery, specifically involved in the non-homologous end joining (NHEJ) pathway. This pathway is vital for repairing double-strand breaks in DNA, which can occur due to various factors such as ionizing radiation, oxidative stress, and during normal cellular processes. Dysregulation of XRCC6BP1 has been implicated in various diseases, including cancer, where faulty repair mechanisms can lead to genomic instability and tumor progression. The study of XRCC6BP1 protein has gained significant attention as researchers aim to elucidate its role in DNA repair, cell survival, and response to genotoxic stress. Understanding the molecular functions and interactions of XRCC6BP1 can provide insights into cancer biology and potential therapeutic targets. Additionally, the exploration of XRCC6BP1 as a recombinant protein allows for the examination of its biochemical properties and interactions in a controlled environment, paving the way for advancements in targeted therapies and personalized medicine. Thus, the investigation of XRCC6BP1 serves as an important avenue in the field of molecular biology and cancer research, with potential implications for improving treatment strategies and outcomes for patients with DNA repair-related disorders.

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