Analytical Data
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基因名
TBCD
- Application
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别名
Beta tubulin cofactor D; Beta-tubulin cofactor D; KIAA0988; SSD 1; SSD-1; SSD1; tbcd; TBCD_HUMAN; tfcD; Tubulin folding cofactor D; Tubulin specific chaperone D; Tubulin-folding cofactor D; Tubulin-specific chaperone D
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BTW9
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表达区间
1-623 aa
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氨基酸序列
MKISHWDGVIRELAARALHNLAQQAPEFSATQVFPRLLSMTLSPDLHTRHGSILACAEVAYALYKLAAQENRPVTDHLDEQAVQGLKQIHQQLYDRQLYRGLGGQLMRQAVCVLIEKLSLSKMPFRGDTVIDGWQWLINDTLRHLHLISSHSRQQMKDAAVSALAALCSEYYMKEPGEADPAIQEELITQYLAELRNPEEMTRCGFSLALGALPGFLLKGRLQQVLTGLRAVTHTSPEDVSFAESRRDGLKAIARICQTVGVKAGAPDEAVCGENVSQIYCALLGCMDDYTTDSRGDVGTWVRKAAMTSLMDLTLLLARSQPELIEAHTCERIMCCVAQQASEKIDRFRAHAASVFLTLLHFDSPPIPHVPHRGELEKLFPRSDVASVNWSAPSQAFPRITQLLGLPTYRYHVLLGLVVSLGGLTESTIRHSTQSLFEYMKGIQSDPQALGSFSGTLLQIFEDNLLNERVSVPLLKTLDHVLTHGCFDIFTTEEDHPFAVKLLALCKKEIKNSKDIQKLLSGIAVFCGMVQFPGDVRRQALLQLCLLLCHRFPLIRKTTASQVYETLLTYSDVVGADVLDEVVTVLSDTAWDAELAVVREQRNRLCDLLGVPRPQLVPQPGAC
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分子量
95.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TBCD (Tubulin Folding Cofactor D) is a crucial protein that plays a significant role in the biogenesis of microtubules, which are essential components of the cytoskeleton in eukaryotic cells. Microtubules are involved in various cellular processes, including maintenance of cell shape, intracellular transport, and cell division. TBCD functions primarily by binding to tubulin dimers and facilitating their correct folding and assembly into microtubules. Research has shown that TBCD is essential for the stability of microtubules and their dynamic behavior, which is vital for proper cellular function. Abnormalities in TBCD expression or function can lead to various diseases, including neurodegenerative disorders and cancer, highlighting its importance in cellular health. Understanding the structure and function of TBCD through recombinant protein studies can provide insights into its mechanisms and potential therapeutic targets. The recombinant production of TBCD enables detailed biochemical and biophysical analyses, allowing researchers to elucidate its interactions with tubulin and other cofactors. Furthermore, studying TBCD’s role in microtubule dynamics and cellular processes can reveal new aspects of cytoskeletal regulation, potentially leading to novel approaches in treating diseases associated with microtubule dysfunction. Overall, TBCD represents a significant focus of research in cell biology, with implications for understanding fundamental cellular mechanisms and developing innovative therapeutic strategies.
