Analytical Data
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Gene name
DUS1L
- Application
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Alternative Names
DUS1LtRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like; EC 1.3.1.-; tRNA-dihydrouridine synthase 1-like
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6P1R4
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Expression Region
1-473aa
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AA Sequence
MPKLQGFEFWSRTLRGARHVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANYRKENLYCEVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGHYGAFLQDEWDLLQRMILLAHEKLSVPVTCKIRVFPEIDKTVRYAQMLEKAGCQLLTVHGRTKEQKGPLSGAASWEHIKAVRKAVAIPVFANGNIQCLQDVERCLRDTGVQGVMSAEGNLHNPALFEGRSPAVWELAEEYLDIVREHPCPLSYVRAHLFKLWHHTLQVHQELREELAKVKTLEGIAAVSQELKLRCQEEISRQEGAKPTGDLPFHWICQPYIRPGPREGSKEKAGARSKRALEEEEGGTEVLSKNKQKKQLRNPHKTFDPSLKPKYAKCDQCGNPKGNRCVFSLCRGCCKKRASKETADCPGHGLLFKTKLEKSLAWKEAQPELQEPQPAAPGTPGGFSEVMGSALA
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Molecular Weight
79.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DUS1L, or double-stranded RNA-specific adenosine deaminase 1-like protein, plays a crucial role in the regulation of gene expression and the innate immune response. Research on DUS1L has gained significant attention due to its involvement in various biological processes, including the modulation of RNA metabolism and immune function. The protein acts as an RNA editing enzyme, converting adenosine to inosine in double-stranded RNA, which can impact the stability and translation of RNA molecules. Additionally, DUS1L has been implicated in the host response to viral infections and may influence the pathogenesis of several diseases, including autoimmune disorders and cancer. Recent studies have focused on understanding the structural characteristics of DUS1L and its functional mechanisms, with the aim of identifying potential therapeutic targets. The ongoing investigation into the recombinant expression of DUS1L facilitates a deeper comprehension of its biochemical properties, interactions with other cellular components, and potential roles in disease progression, paving the way for novel therapeutic strategies in modulating immune responses and targeting RNA-related diseases.
