Analytical Data
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Gene name
TAPBPL
- Application
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Alternative Names
FLJ10143; TAP binding protein like; TAP binding protein related; TAP binding protein related protein; TAP-binding protein-like; TAP-binding protein-related protein; Tapasin like; Tapasin R; Tapasin Related Protein; Tapasin-like; TAPASIN-R; Tapasin-related protein; TAPBP L; TAPBP R; TAPBP-R; Tapbpl; TAPBPR; TPSNR_HUMAN
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BX59
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Expression Region
1-468 aa
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AA Sequence
MGTQEGWCLLLCLALSGAAETKPHPAEGQWRAVDVVLDCFLVKDGAHRGALASSEDRARASLVLKQVPVLDDGSLEDFTDFQGGTLAQDDPPIIFEASVDLVQIPQAEALLHADCSGKEVTCEISRYFLQMTETTVKTAAWFMANVQVSGGGPSISLVMKTPRVAKNEVLWHPTLNLPLSPQGTVRTAVEFQVMTQTQSLSFLLGSSASLDCGFSMAPGLDLISVEWRLQHKGRGQLVYSWTAGQGQAVRKGATLEPAQLGMARDASLTLPGLTIQDEGTYICQITTSLYRAQQIIQLNIQASPKVRLSLANEALLPTLICDIAGYYPLDVVVTWTREELGGSPAQVSGASFSSLRQSVAGTYSISSSLTAEPGSAGATYTCQVTHISLEEPLGASTQVVPPERRTALGVIFASSLFLLALMFLGLQRRQAPTGLGLLQAERWETTSCADTQSSHLHEDRTARVSQPS
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Molecular Weight
76.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
TAPBPL (TAP-binding protein-like) is a protein that has garnered significant attention in recent years due to its role in the immune response, particularly in the regulation of T cell activity and antigen presentation. This protein is involved in the interaction with major histocompatibility complex (MHC) molecules, which are crucial for the recognition of foreign antigens by T cells. Research indicates that TAPBPL modulates the stability and trafficking of MHC class I molecules, thus influencing the presentation of intracellular proteins to CD8+ T cells. Given its pivotal role in immunity, mutations or dysregulation of TAPBPL can lead to immune-related diseases, including autoimmune disorders and cancer. Understanding the structure and function of TAPBPL is essential for developing therapeutic strategies aimed at enhancing immune responses or managing immune dysregulation. Moreover, as researchers delve into TAPBPL's interactions with other proteins and its mechanisms of action, there is potential for discovering novel biomarkers or targets for immunotherapy. Overall, the study of TAPBPL not only contributes to the fundamental understanding of immune biology but also holds promise for novel therapeutic applications in immunodisease.
