Analytical Data
-
Gene name
FRS2
- Application
-
Alternative Names
FRS2；Fibroblast growth factor receptor substrate 2
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q8WU20
-
Expression Region
1-512aa
-
AA Sequence
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTR KRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNM LQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGY PRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTT GVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVK FVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPS VNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYE NLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTV PASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNP QTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTR HNSTDLPMLAWK
-
Molecular Weight
83 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
FRS2 (Fibroblast Growth Factor Receptor Substrate 2) is an intracellular adaptor protein that plays a crucial role in various signaling pathways, particularly those associated with fibroblast growth factor (FGF) receptors. It is involved in processes such as cell proliferation, differentiation, and survival, making it essential for normal development and tissue homeostasis. Dysregulation of FRS2 has been implicated in various diseases, including cancer, where it can contribute to tumor growth and metastasis. The study of FRS2 recombinant proteins has gained significant attention due to their potential applications in understanding these signaling pathways and developing targeted therapies. By using recombinant techniques to produce FRS2, researchers can investigate its structural properties, interaction with other signaling molecules, and downstream effects on cellular functions. This research not only enhances our understanding of FGF signaling mechanisms but also opens avenues for developing therapeutic strategies that could mitigate the effects of abnormal FRS2 activity in diseases. The insights gained from FRS2 studies can contribute to the broader field of signal transduction and cancer biology, ultimately aiding in the discovery of novel interventions for related pathologies. The ongoing exploration of FRS2 functions and its role in regulatory networks continues to be a promising area of research in cellular biology.
