Analytical Data
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基因名
FRS2
- Application
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别名
FRS2；Fibroblast growth factor receptor substrate 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WU20
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表达区间
1-512aa
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氨基酸序列
MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTR KRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNM LQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGY PRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTT GVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVK FVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPS VNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQRRTALLNYE NLPSLPPVWEARKLSRDEDDNLGPKTPSLNGYHNNLDPMHNYVNTENVTV PASAHKIEYSRRRDCTPTVFNFDIRRPSLEHRQLNYIQVDLEGGSDSDNP QTPKTPTTPLPQTPTRRTELYAVIDIERTAAMSNLQKALPRDDGTSRKTR HNSTDLPMLAWK
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分子量
83 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FRS2 (Fibroblast Growth Factor Receptor Substrate 2) is an intracellular adaptor protein that plays a crucial role in various signaling pathways, particularly those associated with fibroblast growth factor (FGF) receptors. It is involved in processes such as cell proliferation, differentiation, and survival, making it essential for normal development and tissue homeostasis. Dysregulation of FRS2 has been implicated in various diseases, including cancer, where it can contribute to tumor growth and metastasis. The study of FRS2 recombinant proteins has gained significant attention due to their potential applications in understanding these signaling pathways and developing targeted therapies. By using recombinant techniques to produce FRS2, researchers can investigate its structural properties, interaction with other signaling molecules, and downstream effects on cellular functions. This research not only enhances our understanding of FGF signaling mechanisms but also opens avenues for developing therapeutic strategies that could mitigate the effects of abnormal FRS2 activity in diseases. The insights gained from FRS2 studies can contribute to the broader field of signal transduction and cancer biology, ultimately aiding in the discovery of novel interventions for related pathologies. The ongoing exploration of FRS2 functions and its role in regulatory networks continues to be a promising area of research in cellular biology.
