Analytical Data
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Gene name
SUV39H2
- Application
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Alternative Names
FLJ23414; H3 K9 HMTase 2; H3-K9-HMTase 2; Histone H3 K9 methyltransferase 2; Histone H3-K9 methyltransferase 2; Histone lysine N methyltransferase H3 lysine 9 specific 2; Histone lysine N methyltransferase SUV39H2; Histone-lysine N-methyltransferase SUV39H2; KMT1B; Lysine N methyltransferase 1B ; Lysine N-methyltransferase 1B; sSuppressor of variegation 3 9 homolog 2 (Drosophila); Su(var)3 9 Drosophila homolog of 2; Su(var)3 9 homolog 2; Su(var)3-9 homolog 2; Suppressor of variegation 3 9 homolog 2; Suppressor of variegation 3-9 homolog 2; Suv39h2; SUV92_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H5I1
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Expression Region
1-410 aa
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AA Sequence
MAAVGAEARG AWCVPCLVSL DTLQELCRKE KLTCKSIGIT KRNLNNYEVE YLCDYKVVKD MEYYLVKWKG WPDSTNTWEP LQNLKCPLLL QQFSNDKHNY LSQVKKGKAI TPKDNNKTLK PAIAEYIVKK AKQRIALQRW QDELNRRKNH KGMIFVENTV DLEGPPSDFY YINEYKPAPG ISLVNEATFG CSCTDCFFQK CCPAEAGVLL AYNKNQQIKI PPGTPIYECN SRCQCGPDCP NRIVQKGTQY SLCIFRTSNG RGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQFYDNK GITYLFDLDY ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR LPRIALFSTR TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRVRTVCKC GAVTCRGYLN
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Molecular Weight
46.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SUV39H2 is a member of the SUV39 protein family, which is primarily involved in histone methylation, a critical process for regulating gene expression and maintaining chromatin structure. Histone methylation plays a vital role in various biological processes, including cell differentiation, development, and responses to environmental stimuli. Dysregulation of histone methylation has been implicated in several diseases, including cancer and neurodegenerative disorders. SUV39H2 is known for its role in trimethylating lysine 9 on histone H3 (H3K9me3), which is a hallmark of heterochromatin formation and transcriptional repression. The study of SUV39H2 and its associated pathways is essential for understanding the intricate mechanisms of epigenetic regulation. Recent research has focused on elucidating the structural and functional characteristics of SUV39H2, as well as its interactions with other proteins and chromatin-modifying enzymes. Investigating the recombinant expression of SUV39H2 provides insights into its enzymatic activity and potential as a therapeutic target. This research has implications not only for basic biology but also for developing novel strategies to manipulate gene expression in therapeutic contexts, thus paving the way for innovative treatments for diseases linked to epigenetic alterations. Understanding the role of SUV39H2 in chromatin dynamics highlights its significance in the broader landscape of epigenetic regulation, making it a focal point for ongoing investigations in molecular biology and drug discovery.
