Analytical Data
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Gene name
WDR13
- Application
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Alternative Names
DKFZp779C2057; FLJ20563; located at OATL1; MG21; WD repeat domain 13; WD repeat-containing Protein 13; WDR13; WDR13_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H1Z4
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Expression Region
1-485 aa
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AA Sequence
MAAVWQQVLA VDARYNAYRT PTFPQFRTQY IRRRSQLLRE NAKAGHPPAL RRQYLRLRGQ LLGQRYGPLS EPGSARAYSN SIVRSSRTTL DRMEDFEDDP RALGARGHRR SVSRGSYQLQ AQMNRAVYED RPPGSVVPTS AAEASRAMAG DTSLSENYAF AGMYHVFDQH VDEAVPRVRF ANDDRHRLAC CSLDGSISLC QLVPAPPTVL RVLRGHTRGV SDFAWSLSND ILVSTSLDAT MRIWASEDGR CIREIPDPDS AELLCCTFQP VNNNLTVVGN AKHNVHVMNI STGKKVKGGS SKLTGRVLAL SFDAPGRLLW AGDDHGSVFS FLFDMATGKL TKAKRLVVHE GSPVTSISAR SWVSREARDP SLLINACLNK LLLYRVVDNE GTLQLKRSFP IEQSSHPVRS IFCPLMSFRQ GACVVTGSED MCVHFFDVER AAKAAVNKLQ GHSAPVLDVS FNCDESLLAS SDASGMVIVW RREQK
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Molecular Weight
53.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
WDR13, or WD repeat domain 13, is a protein implicated in various cellular processes, including protein-protein interactions, cell signaling, and cytoskeletal organization, mainly due to its multiple WD40 repeats. Research into WDR13 has gained traction as its dysregulation has been linked to several diseases, particularly metabolic disorders and cancer. The necessity of understanding WDR13's functional mechanisms arises from its potential role in the pathogenesis of these conditions, making it a candidate for therapeutic targets. Constructing recombinant WDR13 proteins enables scientists to study their structure-function relationships and interactions with other cellular components in vitro. This understanding can shed light on the molecular pathways in which WDR13 is involved and may reveal novel insights into how alterations in its function contribute to disease progression. Moreover, recombinant WDR13 can facilitate the development of specific inhibitors or modulators, opening avenues for new treatments. As the field of protein research expands, the production and characterization of WDR13 in a recombinant form stand as a crucial step toward elucidating its role in health and disease.
