Analytical Data
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基因名
DNAJC7
- Application
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别名
DJ11; DJC7; DnaJ (Hsp40) homolog subfamily C member 7; DnaJ homolog subfamily C member 7; Dnajc7; DNJC7_HUMAN; Tetratricopeptide repeat domain 2; Tetratricopeptide repeat protein 2; TPR repeat protein 2; TPR2; TTC2
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99615
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表达区间
1-484aa
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氨基酸序列
MAATEPELLDDQEAKREAETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILKAECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGNKAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLDDTYIKAYLRRAQCYMDTEQYEEAVRDYEKVYQTEKTKEHKQLLKNAQLELKKSKRKDYYKILGVDKNASEDEIKKAYRKRALMHHPDRHSGASAEVQKEEEKKFKEVGEAFTILSDPKKKTRYDSGQDLDEEGMNMGDFDPNNIFKAFFGGPGGFSFEASGPGNFFFQFG
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分子量
78.98 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJC7, a member of the DnaJ homolog protein family, plays a crucial role in protein folding and management within the cellular environment. Research has shown that DNAJC7 is involved in various cellular processes, including the stress response and protein quality control, primarily through its interaction with heat shock proteins. Its unique structure, characterized by a J-domain, enables it to facilitate the proper folding of nascent polypeptides and the refolding of misfolded proteins. Recent studies have highlighted the significance of DNAJC7 in neurodegenerative diseases, where misfolded proteins accumulate, leading to cellular dysfunction. Its potential as a therapeutic target is underscored by its involvement in pathways related to protein aggregation and cellular stress. Understanding the functional mechanisms of DNAJC7 through the production of recombinant protein can provide valuable insights into its role in cellular homeostasis and disease pathogenesis. Consequently, the research on DNAJC7 recombinant proteins is not only central to deciphering its biological functions but also pivotal in developing therapeutic strategies for conditions associated with protein misfolding, thus opening new avenues in molecular biology and medicine.
