Analytical Data
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基因名
DNAJB7
- Application
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别名
DJ5; DnaJ (Hsp40) homolog subfamily B member 7; DnaJ homolog subfamily B member 7; DnaJ/Hsp40 homolog subfamily B; member 7; DNAJB7; DNJB7_HUMAN; HSC3; MGC138340; Novel DnaJ domain protein
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7Z6W7
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表达区间
1-309aa
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氨基酸序列
MVDYYEVLGL QRYASPEDIK KAYHKVALKW HPDKNPENKE EAERKFKEVA EAYEVLSNDE KRDIYDKYGT EGLNGGGSHF DDECEYGFTF HKPDDVFKEI FHERDPFSFH FFEDSLEDLL NRPGSSYGNR NRDAGYFFST ASEYPIFEKF SSYDTGYTSQ GSLGHEGLTS FSSLAFDNSG MDNYISVTTS DKIVNGRNIN TKKIIESDQE REAEDNGELT FFLVNSVANE EGFAKECSWR TQSFNNYSPN SHSSKHVSQY TFVDNDEGGI SWVTSNRDPP IFSAGVKEGG KRKKKKRKEV QKKSTKRNC
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分子量
61.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DNAJB7, a member of the DnaJ/Hsp40 family of heat shock proteins, plays a critical role in protein folding and cellular stress responses. Its primary function is to assist in the proper folding of nascent polypeptides and the refolding of misfolded proteins, thereby maintaining cellular homeostasis. The significance of DNAJB7 has gained attention due to its involvement in various cellular processes, including chaperone-mediated protein quality control, which is vital for cell survival under stress conditions. Research has revealed that DNAJB7 may influence several diseases, including neurodegenerative disorders and cancer, by modulating the stability and aggregation of proteins associated with these conditions. The recombinant protein of DNAJB7 is being studied to elucidate its specific mechanisms of action, structural properties, and interactions with substrate proteins. Understanding the functional dynamics of DNAJB7 could provide insights into therapeutic strategies aimed at enhancing cellular resilience against stress and misfolded protein accumulation. Moreover, the potential of DNAJB7 as a biomarker for disease diagnosis and prognosis has prompted ongoing investigations into its role in disease mechanisms, making it a focus of significant interest in molecular biology and biomedicine. Through these research efforts, scientists aim to exploit the chaperone functions of DNAJB7 for developing novel therapeutic interventions that target protein misfolding diseases.
