Analytical Data
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Gene name
STK33
- Application
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Alternative Names
Hypothetical protein FLJ35932; Serine threonine kinase 33; Serine/threonine kinase 33; Serine/threonine protein kinase 33; Serine/threonine-protein kinase 33; STK 33; Stk33; STK33_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BYT3
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Expression Region
1-514 aa
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AA Sequence
MADSGLDKKS TKCPDCSSAS QKDVLCVCSS KTRVPPVLVV EMSQTSSIGS AESLISLERK KEKNINRDIT SRKDLPSRTS NVERKASQQQ WGRGNFTEGK VPHIRIENGA AIEEIYTFGR ILGKGSFGIV IEATDKETET KWAIKKVNKE KAGSSAVKLL EREVNILKSV KHEHIIHLEQ VFETPKKMYL VMELCEDGEL KEILDRKGHF SENETRWIIQ SLASAIAYLH NNDIVHRDLK LENIMVKSSL IDDNNEINLN IKVTDFGLAV KKQSRSEAML QATCGTPIYM APEVISAHDY SQQCDIWSIG VVMYMLLRGE PPFLASSEEK LFELIRKGEL HFENAVWNSI SDCAKSVLKQ LMKVDPAHRI TAKELLDNQW LTGNKLSSVR PTNVLEMMKE WKNNPESVEE NTTEEKNKPS TEEKLKSYQP WGNVPDANYT SDEEEEKQST AYEKQFPATS KDNFDMCSSS FTSSKLLPAE IKGEMEKTPV TPSQGTATKY PAKSGALSRT KKKL
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Molecular Weight
57.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
STK33 (Serine/Threonine Kinase 33) is a protein that has garnered significant attention in cancer research due to its potential role in oncogenic signaling pathways and cellular stress responses. Initially identified as a putative kinase, STK33 is believed to be involved in regulating cell proliferation, survival, and apoptosis, making it a candidate of interest in understanding tumorigenesis. Studies have demonstrated that STK33 is overexpressed in various cancer types, suggesting that it may function as an oncogene by promoting the growth and survival of malignant cells. Additionally, its involvement in the stress response mechanisms, particularly under conditions of hypoxia or nutrient deprivation, highlights its importance in cancer cell adaptation and resilience. Researchers have been exploring the therapeutic potential of targeting STK33, aiming to develop inhibitors that can disrupt its activity and sensitize cancer cells to conventional treatments. Furthermore, structural studies and the generation of recombinant STK33 proteins have paved the way for a deeper understanding of its biochemical properties and interactions with other cellular signaling molecules. Overall, ongoing research into STK33 aims to unravel its precise biological functions and establish a foundation for novel cancer therapies.
