Analytical Data
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Gene name
STK35
- Application
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Alternative Names
CLIK-1; Clik1; CLP 36 interacting kinase; CLP-36-interacting kinase 1; EC 2.7.1.37; PDLIM1 interacting kinase; PDLIM1-interacting kinase 1; Serine threonine kinase 35 long form; Serine/threonine kinase 35; Serine/threonine protein kinase 35; Serine/threonine-protein kinase 35; Serine/threonine-protein kinase 35 L1; STK35; STK35_HUMAN; STK35L1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TDR2
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Expression Region
1-534 aa
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AA Sequence
MGHQESPLAR APAGGAAYVK RLCKGLSWRE HVESHGSLGA QASPASAAAA EGSATRRARA ATSRAARSRR QPGPGADHPQ AGAPGGKRAA RKWRCAGQVT IQGPAPPRPR AGRRDEAGGA RAAPLLLPPP PAAMETGKDG ARRGTQSPER KRRSPVPRAP STKLRPAAAA RAMDPVAAEA PGEAFLARRR PEGGGGSARP RYSLLAEIGR GSYGVVYEAV AGRSGARVAV KKIRCDAPEN VELALAEFWA LTSLKRRHQN VVQFEECVLQ RNGLAQRMSH GNKSSQLYLR LVETSLKGER ILGYAEEPCY LWFVMEFCEG GDLNQYVLSR RPDPATNKSF MLQLTSAIAF LHKNHIVHRD LKPDNILITE RSGTPILKVA DFGLSKVCAG LAPRGKEGNQ DNKNVNVNKY WLSSACGSDF YMAPEVWEGH YTAKADIFAL GIIIWAMIER ITFIDSETKK ELLGTYIKQG TEIVPVGEAL LENPKMELHI PQKRRTSMSE GIKQLLKDML AANPQDRPDA FELETRMDQV TCAA
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Molecular Weight
58.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
STK35, a serine/threonine kinase, has garnered attention in recent years due to its potential roles in various cellular processes, including proliferation, differentiation, and apoptosis. Research indicates that STK35 is involved in signaling pathways that govern cell survival and metabolism, which could have implications for understanding diseases such as cancer and metabolic disorders. The interest in STK35 is further fueled by its potential as a therapeutic target, as modulating its activity may influence cancer cell growth and response to treatment. Additionally, STK35 has been implicated in regulating the immune response, highlighting its possible role in inflammatory diseases. Recombinant STK35 proteins have been generated for experimental purposes, enabling researchers to delineate the kinase's structural and functional characteristics, assess its enzymatic activity, and explore its interactions with other cellular components. This research could pave the way for novel therapeutic strategies aimed at manipulating STK35 activity in various pathological conditions. Understanding the mechanisms underlying STK35's involvement in cellular signaling is critical for developing targeted therapies that could enhance cancer treatment efficacy and improve patient outcomes. As the field advances, further elucidation of STK35's biological roles and interactions will be essential for leveraging its pharmacological potential.
