Analytical Data
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基因名
VPS37A
- Application
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别名
VPS37A; HCRP1; Vacuolar Protein sorting-associated Protein 37A; hVps37A; ESCRT-I complex subunit VPS37A; Hepatocellular carcinoma-related Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NEZ2
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表达区间
1-397 aa
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氨基酸序列
MSWLFPLTKS ASSSAAGSPG GLTSLQQQKQ RLIESLRNSH SSIAEIQKDV EYRLPFTINN LTININILLP PQFPQEKPVI SVYPPIRHHL MDKQGVYVTS PLVNNFTMHS DLGKIIQSLL DEFWKNPPVL APTSTAFPYL YSNPSGMSPY ASQGFPFLPP YPPQEANRSI TSLSVADTVS SSTTSHTTAK PAAPSFGVLS NLPLPIPTVD ASIPTSQNGF GYKMPDVPDA FPELSELSVS QLTDMNEQEE VLLEQFLTLP QLKQIITDKD DLVKSIEELA RKNLLLEPSL EAKRQTVLDK YELLTQMKST FEKKMQRQHE LSESCSASAL QARLKVAAHE AEEESDNIAE DFLEGKMEID DFLSSFMEKR TICHCRRAKE EKLQQAIAMH SQFHAPL
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分子量
44.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VPS37A, a crucial component of the ESCRT (endosomal sorting complexes required for transport) machinery, plays a significant role in cellular processes such as protein trafficking, endosomal sorting, and the degradation of cell surface receptors. Recent studies have highlighted its involvement in the modulation of various signaling pathways and its implications in the pathogenesis of multiple diseases, including cancer and neurodegenerative disorders. The understanding of VPS37A's structure and function is essential for elucidating its role in cellular homeostasis and disease progression. Recombinant expression of VPS37A is imperative for functional studies, as it allows researchers to investigate the protein's interactions with other ESCRT components and assess its activity within different cellular contexts. Additionally, studying the post-translational modifications and dynamics of VPS37A can provide insights into its regulatory mechanisms and potential therapeutic targets. Overall, the research into VPS37A's recombinant protein design is a promising avenue for advancing our understanding of cellular dysfunctions and developing novel strategies for intervention in various diseases.
