Analytical Data
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基因名
VPS36
- Application
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别名
C13orf9; CGI 145; EAP45; ELL associated Protein of 45 kDa; ELL-associated Protein of 45 kDa; ESCRT-II complex subunit VPS36; Vacuolar Protein sorting associated Protein 36; Vacuolar Protein-sorting-associated Protein 36; Vps36; VPS36_HUMAN
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q86VN1
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表达区间
1-386 aa
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氨基酸序列
MDRFVWTSGL LEINETLVIQ QRGVRIYDGE EKIKFDAGTL LLSTHRLIWR DQKNHECCMA ILLSQIVFIE EQAAGIGKSA KIVVHLHPAP PNKEPGPFQS SKNSYIKLSF KEHGQIEFYR RLSEEMTQRR WENMPVSQSL QTNRGPQPGR IRAVGIVGIE RKLEEKRKET DKNISEAFED LSKLMIKAKE MVELSKSIAN KIKDKQGDIT EDETIRFKSY LLSMGIANPV TRETYGSGTQ YHMQLAKQLA GILQVPLEER GGIMSLTEVY CLVNRARGME LLSPEDLVNA CKMLEALKLP LRLRVFDSGV MVIELQSHKE EEMVASALET VSEKGSLTSE EFAKLVGMSV LLAKERLLLA EKMGHLCRDD SVEGLRFYPN LFMTQS
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分子量
43.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
VPS36, a protein that belongs to the eukaryotic VPS (vacuolar protein sorting) family, plays a crucial role in intracellular trafficking and the sorting of membrane proteins. It is part of the ESCRT (endosomal sorting complex required for transport) machinery, which is essential for the biogenesis of multivesicular bodies and the degradation of membrane proteins in lysosomes. Research has shown that VPS36 is involved in various cellular processes, including autophagy, immune response, and viral entry, making it a key player in maintaining cellular homeostasis. Abnormalities in VPS36 expression or function have been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Recent studies have focused on elucidating the structural and functional aspects of VPS36, including its interactions with other ESCRT components and membrane proteins, aiming to uncover the detailed mechanisms by which it contributes to cellular processes. Understanding the role of VPS36 in cellular dynamics not only provides insights into fundamental biological mechanisms but also paves the way for novel strategies in disease treatment and prevention.
